Effect of time of day on walking capacity and self-reported fatigue in persons with multiple sclerosis: a multi-center trial

Background: Many persons with multiple sclerosis (PwMS) report increased fatigue in the afternoon and evening compared with the morning. It is commonly accepted that physical capacity also decreases as time of day progresses, potentially influencing the outcomes of testing. Objective: The objective...

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Bibliographic Details
Published in:Multiple sclerosis 2012-03, Vol.18 (3), p.351-357
Main Authors: Feys, P, Gijbels, D, Romberg, A, Santoyo, C, Gebara, B, de Noordhout, B Maertens, Knuts, K, Béthoux, F, de Groot, V, Vaney, C, Dalgas, U
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Disability Evaluation
Fatigue - complications
Fatigue - physiopathology
Female
Humans
Male
Medical sciences
Middle Aged
Multiple Sclerosis - complications
Multiple Sclerosis - physiopathology
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Neurology
Self Report
Time Factors
Walking - physiology
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Summary:Background: Many persons with multiple sclerosis (PwMS) report increased fatigue in the afternoon and evening compared with the morning. It is commonly accepted that physical capacity also decreases as time of day progresses, potentially influencing the outcomes of testing. Objective: The objective of this article was to determine whether self-reported fatigue level and walking capacity are influenced by time of day in PwMS. Methods: A total of 102 PwMS from 8 centers in 5 countries, with a diverse level of ambulatory dysfunction (Expanded Disability Status Scale [EDSS]
ISSN:1352-4585
1477-0970
DOI:10.1177/1352458511419881