Leptin reduces hyperactivity in an animal model for anorexia nervosa via the ventral tegmental area

Abstract Hyperactivity in anorexia nervosa (AN) is associated with low plasma leptin levels and negatively impacts on disease outcome. Using an animal model that mimics features of AN including food-restriction induced hyperlocomotion, we demonstrate that central leptin injections in the lateral ven...

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Bibliographic Details
Published in:European neuropsychopharmacology 2011-03, Vol.21 (3), p.274-281
Main Authors: Verhagen, Linda A.W, Luijendijk, Mieneke C.M, Adan, Roger A.H
Format: Article
Language:English
Subjects:
Activity-based anorexia
Animals
Anorexia nervosa
Anorexia Nervosa - physiopathology
Body Weight - drug effects
Disease Models, Animal
Eating - drug effects
Female
Hyperactivity
Hyperkinesis - physiopathology
Infusions, Intraventricular
Insulin - blood
Internal Medicine
Leptin
Leptin - administration & dosage
Leptin - blood
Motor Activity - drug effects
Psychiatry
Rats
Rats, Wistar
Running wheel activity
Ventral tegmental area
Ventral Tegmental Area - drug effects
Ventral Tegmental Area - physiopathology
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Summary:Abstract Hyperactivity in anorexia nervosa (AN) is associated with low plasma leptin levels and negatively impacts on disease outcome. Using an animal model that mimics features of AN including food-restriction induced hyperlocomotion, we demonstrate that central leptin injections in the lateral ventricle and local injections of leptin into the ventral tegmental area (VTA) suppress running wheel activity. The results support that falling levels of leptin, that accompany caloric restriction, result in increased activity levels because of decreased leptin signaling in the VTA, part of the mesolimbic reward system.
ISSN:0924-977X
1873-7862
DOI:10.1016/j.euroneuro.2010.11.006