Calcium absorption in postmenopausal osteoporosis : Benefit of HRT plus calcitriol, but not HRT alone, in both malabsorbers and normal absorbers

In a randomized trial involving 71 postmenopausal osteoporotic women with vertebral compression fractures, radiocalcium absorption studies using the (45)Ca single isotope method (alpha) were performed at baseline and after 8 months of treatment with either continuous combined hormone replacement the...

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Bibliographic Details
Published in:Osteoporosis international 2000, Vol.11 (1), p.43-51
Main Authors: HOLZHERR, M. L, RETALLACK, R. W, CRIDDLE, R. A, KENT, G. N, BHAGAT, C. I, DHALIWAL, S. S, JAMROZIK, K, GUTTERIDGE, D. H, PRICE, R. I, FAULKNER, D. L, WILSON, S. G, WILL, R. K, STEWART, G. O, STUCKEY, B. G. A, PRINCE, R. L
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Bone Density - physiology
Bones, joints and connective tissue. Antiinflammatory agents
Calcitriol - administration & dosage
Calcitriol - metabolism
Calcium - administration & dosage
Calcium - metabolism
Estrogen Replacement Therapy - methods
Female
Humans
Intestinal Absorption - physiology
Malabsorption Syndromes - complications
Malabsorption Syndromes - metabolism
Medical sciences
Middle Aged
Osteoporosis, Postmenopausal - drug therapy
Osteoporosis, Postmenopausal - metabolism
Pharmacology. Drug treatments
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Summary:In a randomized trial involving 71 postmenopausal osteoporotic women with vertebral compression fractures, radiocalcium absorption studies using the (45)Ca single isotope method (alpha) were performed at baseline and after 8 months of treatment with either continuous combined hormone replacement therapy (HRT, as piperazine estrone sulfate 0.625-0.937 mg daily +/- medroxyprogesterone acetate 2.5 mg daily depending on uterine status) or HRT plus calcitriol 0. 25 microg twice daily. A calcium supplement of 600 mg nocte was given to only those women who had a daily calcium intake of less than 1 g per day at baseline, as assessed by recalled dietary intake. There was a significant decrease [0.74 (+/- 0.35 SD) to 0.58 (+/- 0. 22), Dalpha = -0.17 (+/- 0.26), p
ISSN:0937-941X
1433-2965
DOI:10.1007/s001980050005