Bone marrow lesions in people with knee osteoarthritis predict progression of disease and joint replacement: a longitudinal study

Objectives. The presence of bone marrow lesions (BMLs) has been linked to pain and progression of knee OA. The aim of this study was to determine the relationship between BMLs and longitudinal change in tibial cartilage volume and risk of knee joint replacement in subjects with knee OA. Methods. One...

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Bibliographic Details
Published in:Rheumatology (Oxford, England) England), 2010-12, Vol.49 (12), p.2413-2419
Main Authors: Tanamas, Stephanie K., Wluka, Anita E., Pelletier, Jean-Pierre, Pelletier, Johanne M., Abram, François, Berry, Patricia A., Wang, Yuanyuan, Jones, Graeme, Cicuttini, Flavia M.
Format: Article
Language:English
Subjects:
Aged
Arthroplasty, Replacement, Knee
Biological and medical sciences
Bone Marrow Diseases - pathology
Bone Marrow Diseases - surgery
Bone marrow lesions
Cartilage loss
Cartilage, Articular
Disease Progression
Diseases of the osteoarticular system
Female
Humans
Knee - surgery
Knee Joint - surgery
Knee joint replacement
Longitudinal Studies
Magnetic Resonance Imaging - methods
Male
Medical sciences
Middle Aged
Miscellaneous. Osteoarticular involvement in other diseases
Orthopedic surgery
Osteoarthritis
Osteoarthritis, Knee - pathology
Osteoarthritis, Knee - surgery
Risk Factors
Statistics as Topic
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Tibial cartilage
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Summary:Objectives. The presence of bone marrow lesions (BMLs) has been linked to pain and progression of knee OA. The aim of this study was to determine the relationship between BMLs and longitudinal change in tibial cartilage volume and risk of knee joint replacement in subjects with knee OA. Methods. One hundred and nine men and women with symptomatic knee OA were recruited. The same knee was imaged using MRI at baseline and ∼2 years later. Tibial cartilage volume and BMLs were measured. Knee joint replacement over 4 years was determined. Results. The mean age of the subjects at baseline was 63.2 (s.d. 10.3) years. BMLs were present in 66% of the subjects. Cross-sectionally, BMLs were negatively associated with both medial (regression coefficient −121.4; 95% CI −183.8, −859.1; P 
ISSN:1462-0324
1462-0332
DOI:10.1093/rheumatology/keq286