Genetic variations in vascular endothelial growth factor but not in angiotensin I-converting enzyme genes are associated with endometriosis in Estonian women

Abstract Objective To determine plausible associations between endometriosis and vascular endothelial growth factor gene ( VEGF −2578 A/C, −1154 G/A, −634 G/C and 936 C/T), also angiotensin I-converting enzyme gene ( ACE −240 A/T and 2350 A/G) single nucleotide polymorphisms (SNPs), as well as their...

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Published in:European journal of obstetrics & gynecology and reproductive biology 2010-11, Vol.153 (1), p.85-89
Main Authors: Lamp, Merit, Saare, Merli, Laisk, Triin, Karro, Helle, Kadastik, Ülle, Metspalu, Andres, Peters, Maire, Salumets, Andres
Format: Article
Language:English
Subjects:
ACE
Adolescent
Adult
Biological and medical sciences
Case-Control Studies
Endometriosis
Endometriosis - genetics
Estonia
Female
Female genital diseases
Genotype
Gynecology. Andrology. Obstetrics
Haplotypes
Humans
Medical sciences
Middle Aged
Non tumoral diseases
Obstetrics and Gynecology
Peptidyl-Dipeptidase A - genetics
Polymorphism, Single Nucleotide
Single nucleotide polymorphisms
Vascular Endothelial Growth Factor A - genetics
VEGF
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Summary:Abstract Objective To determine plausible associations between endometriosis and vascular endothelial growth factor gene ( VEGF −2578 A/C, −1154 G/A, −634 G/C and 936 C/T), also angiotensin I-converting enzyme gene ( ACE −240 A/T and 2350 A/G) single nucleotide polymorphisms (SNPs), as well as their respective haplotypes. Study design PCR-based restriction fragment length polymorphism analysis was used to detect SNPs in VEGF and ACE genes in 150 Estonian women with endometriosis and 199 control subjects. Results The CC genotype of the VEGF −2578 A/C SNP was correlated with a decreased risk of endometriosis (OR = 0.40, 95% CI 0.20–0.78). Other VEGF and ACE SNPs and haplotypes were not associated with endometriosis. Conclusion This case-control study demonstrated that the VEGF −2578 A/C SNP may influence susceptibility to endometriosis in the Estonian population, while associations between endometriosis and other VEGF and ACE SNPs, as well as the respective haplotypes are unlikely.
ISSN:0301-2115
1872-7654
DOI:10.1016/j.ejogrb.2010.07.021