Prophylactic ventral cardiac denervation: Does it reduce incidence of atrial fibrillation after coronary artery bypass grafting?

Objective This study assessed the prophylactic effect of ventral cardiac denervation on reducing atrial fibrillation after coronary artery bypass grafting. Methods This randomized prospective study recruited 220 adult patients (aged 42–79 years) who were scheduled to undergo coronary artery bypass g...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of thoracic and cardiovascular surgery 2010-11, Vol.140 (5), p.1036-1039
Main Authors: Salehi Omran, Abbas, MD, Karimi, Abbasali, MD, Ahmadi, Hossein, MD, Yazdanifard, Parin, MD, Sheikh Fahtollahi, Mahmood, PhD, Tazik, Mokhtar, MD
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Atrial Fibrillation - epidemiology
Atrial Fibrillation - etiology
Atrial Fibrillation - prevention & control
Biological and medical sciences
Cardiac dysrhythmias
Cardiology. Vascular system
Cardiothoracic Surgery
Chi-Square Distribution
Coronary Artery Bypass - adverse effects
Coronary heart disease
Denervation - adverse effects
Female
Heart
Heart - innervation
Humans
Incidence
Iran
Logistic Models
Male
Medical sciences
Middle Aged
Odds Ratio
Pneumology
Prospective Studies
Risk Assessment
Risk Factors
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective This study assessed the prophylactic effect of ventral cardiac denervation on reducing atrial fibrillation after coronary artery bypass grafting. Methods This randomized prospective study recruited 220 adult patients (aged 42–79 years) who were scheduled to undergo coronary artery bypass grafting. Of these patients, 110 underwent ventral cardiac denervation in addition to coronary artery bypass grafting and 110 underwent only coronary artery bypass grafting. The demographic, intraoperative, and postoperative factors comprising atrial fibrillation were compared between the 2 groups. In addition, the predictive factors of atrial fibrillation in all 220 cases were assessed. Results The mean age and the distribution of gender, body mass index, diabetes mellitus, chronic obstructive pulmonary disease, hypertension, hypercholesterolemia, and left main disease were not significantly different between the 2 groups. Atrial fibrillation incidence was significantly different between the groups ( P = .025), with an incidence of 20.9% in the ventral cardiac denervation group and 10% in the control group. Atrial fibrillation occurred in 34 of the 220 patients, and ventral cardiac denervation was considered as a variable to evaluate its possible role in the prevention of postoperative atrial fibrillation. Our multivariate analysis showed age ( P = .002; odds ratio, 1.098; confidence interval, 1.034–1.165) and ventral cardiac denervation ( P = .044; odds ratio, 2.32; confidence interval, 1022–5.298) as the predictive factors of atrial fibrillation after coronary artery bypass grafting. Conclusions Given the surprising results of the present study demonstrating that ventral cardiac denervation is a predictive factor of atrial fibrillation after coronary artery bypass grafting, ventral cardiac denervation should not be routinely considered for the prevention of atrial fibrillation after coronary artery bypass grafting.
ISSN:0022-5223
1097-685X
DOI:10.1016/j.jtcvs.2009.12.024