Smoking influences salivary histamine levels in periodontal disease

Oral Diseases (2012) 18, 410–416 Objectives:  Histamine, a potent vasoactive amine, is increased in saliva of periodontitis patients. The present study aimed to further investigate the diagnostic potential of histamine for periodontal disease and assessed smoking, a major risk factor of periodontiti...

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Published in:Oral diseases 2012-05, Vol.18 (4), p.410-416
Main Authors: Bertl, K, Haririan, H, Laky, M, Matejka, M, Andrukhov, O, Rausch-Fan, X
Format: Article
Language:English
Subjects:
Adult
Alveolar Bone Loss - blood
Alveolar Bone Loss - metabolism
C-Reactive Protein - analysis
Dentistry
Disease
Female
Gingival Hemorrhage - blood
Gingival Hemorrhage - metabolism
Histamine
Histamine - analysis
Histamine - blood
Histamine Agonists - analysis
Histamine Agonists - blood
Humans
Inflammation Mediators - analysis
Inflammation Mediators - blood
Male
Oral hygiene
Periodontal Attachment Loss - blood
Periodontal Attachment Loss - metabolism
periodontal diagnostics
periodontal disease
Periodontal Pocket - blood
Periodontal Pocket - metabolism
Periodontitis - metabolism
Proteins
saliva
Saliva - metabolism
Smoking
Smoking - blood
Smoking - metabolism
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Summary:Oral Diseases (2012) 18, 410–416 Objectives:  Histamine, a potent vasoactive amine, is increased in saliva of periodontitis patients. The present study aimed to further investigate the diagnostic potential of histamine for periodontal disease and assessed smoking, a major risk factor of periodontitis, as a possible influencing factor. Methods:  Salivary and serum samples of 106 participants (60 periodontitis patients, 46 controls) were collected. Salivary histamine was determined by a commercially available ELISA kit, and serum C‐reactive protein was measured by a routine laboratory test. Cigarettes per day and packyears were assessed as smoking exposure parameters. Results:  Statistically significantly increased levels of salivary histamine and serum C‐reactive protein were detected between the patient and control group (P = 0.022 and P = 0.001). Salivary histamine levels were significantly higher in smoking compared with non‐smoking patients (P 
ISSN:1354-523X
1601-0825
DOI:10.1111/j.1601-0825.2011.01891.x