Link between chronic obstructive pulmonary disease and coronary artery disease: Implication for clinical practice

ABSTRACT Chronic obstructive pulmonary disease (COPD) and coronary artery disease (CAD) are global epidemics that incur significant morbidity and mortality. These diseases are frequently found in combination, and they can also be found independent of the common causal factors, primarily smoking. Bot...

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Bibliographic Details
Published in:Respirology (Carlton, Vic.) Vic.), 2012-04, Vol.17 (3), p.422-431
Main Authors: BOSCHETTO, PIERA, BEGHÉ, BIANCA, FABBRI, LEONARDO M., CECONI, CLAUDIO
Format: Article
Language:English
Subjects:
cardiovascular disease
chronic obstructive pulmonary disease
clinical epidemiology
Comorbidity
Coronary Artery Disease - epidemiology
Coronary Artery Disease - physiopathology
Coronary Artery Disease - prevention & control
Disease Progression
emphysema
Female
Humans
inflammation
Male
Myocardial Revascularization
Practice Guidelines as Topic
Prevalence
Prognosis
Pulmonary Disease, Chronic Obstructive - epidemiology
Pulmonary Disease, Chronic Obstructive - physiopathology
Severity of Illness Index
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Summary:ABSTRACT Chronic obstructive pulmonary disease (COPD) and coronary artery disease (CAD) are global epidemics that incur significant morbidity and mortality. These diseases are frequently found in combination, and they can also be found independent of the common causal factors, primarily smoking. Both conditions are systemic disorders with overlapping mechanisms and pathophysiologic processes. CAD has a strong effect on the severity and prognosis of COPD and vice versa, including acute exacerbations. Even the most recent practical clinical recommendations driven by Clinical Practice Guidelines still focus on one disease at a time, and do not provide advice for the management of patients with associated chronic conditions. COPD should be approached in a more comprehensive manner, including the treatment of cardiac comorbidities, particularly CAD. To focus treatment on these comorbidities might modify the natural course of the disease in patients with COPD who may not find relief from treatment of COPD alone.
ISSN:1323-7799
1440-1843
DOI:10.1111/j.1440-1843.2011.02118.x