Cytomegalovirus Infection During Pregnancy With Maternofetal Transmission Induces a Proinflammatory Cytokine Bias in Placenta and Amniotic Fluid

Congenital infection with cytomegalovirus (CMV) can induce immune responses and placental damage. By use of immunoassay panels, 27 cytokines were assessed in midtrimester amniotic fluid from 8 patients with congenital CMV, in midtrimester sera from 12 pregnant women with primary CMV infection, and i...

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Bibliographic Details
Published in:The Journal of infectious diseases 2012-04, Vol.205 (8), p.1305-1310
Main Authors: Scott, Gillian M., Chow, Sharon S. W., Craig, Maria E., Pang, Chi N. I., Hall, Beverley, Wilkins, Marc R., Jones, Cheryl A., Lloyd, Andrew R., Rawlinson, William D.
Format: Article
Language:English
Subjects:
Adult
Amniotic fluid
Amniotic Fluid - metabolism
Biological and medical sciences
Chemokines
Cluster Analysis
Cytokines
Cytokines - metabolism
Cytomegalovirus
Cytomegalovirus Infections - transmission
Female
Fundamental and applied biological sciences. Psychology
Gene Expression Profiling
Gene Expression Regulation
Humans
Infant, Newborn
Infections
Infectious Disease Transmission, Vertical
Infectious diseases
Interleukins
Medical sciences
Microbiology
Placenta
Placenta - metabolism
Pregnancy
Pregnancy Complications, Infectious - pathology
Trophoblasts
VIRUSES
Women
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Summary:Congenital infection with cytomegalovirus (CMV) can induce immune responses and placental damage. By use of immunoassay panels, 27 cytokines were assessed in midtrimester amniotic fluid from 8 patients with congenital CMV, in midtrimester sera from 12 pregnant women with primary CMV infection, and in amniotic fluid and serum from uninfected maternal controls. Levels of the cytokines tumor necrosis factor α, interleukin 1β, interleukin 12, and interleukin 17; the chemokines CCL2, CCL4, and CXCL10; and the growth factors granulocyte-macrophage colony-stimulating factor and platelet-derived growth factor bb were significantly elevated in amniotic fluid from congenital CMV patients (P < .01). Only CXCL10 was significantly higher in sera from CMV-infected pregnant women. CMV infection during pregnancy is associated with a shift in cytokine expression toward a proinflammatory state.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jis186