Loading…
Dietary flavonoid intakes and risk of type 2 diabetes in US men and women
Data from mechanistic studies support a beneficial effect of specific flavonoids on insulin sensitivity. However, few studies have evaluated the relation between intakes of different flavonoid subclasses and type 2 diabetes. The objective was to evaluate whether dietary intakes of major flavonoid su...
Saved in:
| Published in: | The American journal of clinical nutrition 2012-04, Vol.95 (4), p.925-933 |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c440t-b3ac108844ebfe186c45fab5222026a0496b21949d16db355c39a5abdbbf845f3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c440t-b3ac108844ebfe186c45fab5222026a0496b21949d16db355c39a5abdbbf845f3 |
| container_end_page | 933 |
| container_issue | 4 |
| container_start_page | 925 |
| container_title | The American journal of clinical nutrition |
| container_volume | 95 |
| creator | WEDICK, Nicole M AN PAN CASSIDY, Aedín RIMM, Eric B SAMPSON, Laura ROSNER, Bernard WILLETT, Walter HU, Frank B QI SUN DAM, Rob M.van |
| description | Data from mechanistic studies support a beneficial effect of specific flavonoids on insulin sensitivity. However, few studies have evaluated the relation between intakes of different flavonoid subclasses and type 2 diabetes.
The objective was to evaluate whether dietary intakes of major flavonoid subclasses (ie, flavonols, flavones, flavanones, flavan-3-ols, and anthocyanins) are associated with the risk of type 2 diabetes in US adults.
We followed up a total of 70,359 women in the Nurses' Health Study (NHS; 1984-2008), 89,201 women in the NHS II (1991-2007), and 41,334 men in the Health Professionals Follow-Up Study (1986-2006) who were free of diabetes, cardiovascular disease, and cancer at baseline.
During 3,645,585 person-years of follow-up, we documented 12,611 incident cases of type 2 diabetes. Higher intakes of anthocyanins were significantly associated with a lower risk of type 2 diabetes (pooled HR for the 3 cohorts from a comparison of extreme quintiles: 0.85; 95% CI: 0.80, 0.91; P-trend < 0.001) after multivariate adjustment for age, BMI, and lifestyle and dietary factors. Consumption of anthocyanin-rich foods, particularly blueberries (pooled HR: 0.77 from a comparison of ≥2 servings/wk with |
| doi_str_mv | 10.3945/ajcn.111.028894 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_934268770</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>934268770</sourcerecordid><originalsourceid>FETCH-LOGICAL-c440t-b3ac108844ebfe186c45fab5222026a0496b21949d16db355c39a5abdbbf845f3</originalsourceid><addsrcrecordid>eNpd0E1LwzAYwPEgipsvZ28SBPHUmfcmR5lvA8GDeg5JmkK2Np1Np-zbm7mp4CmB_J6H8AfgDKMJVYxfm7mLE4zxBBEpFdsDY6yoLChB5T4YI4RIobDgI3CU0hwhTJgUh2BECOVlSegYzG6DH0y_hnVjPrrYhQqGOJiFT9DECvYhLWBXw2G99JDAKhjrh_wWInx7ga2P3-qzy7cTcFCbJvnT3XkM3u7vXqePxdPzw2x681Q4xtBQWGocRlIy5m3tsRSO8dpYTghBRBjElLAEK6YqLCpLOXdUGW5sZW0tM6XH4Gq7d9l37yufBt2G5HzTmOi7VdKKMiJkWaIsL_7JebfqY_6cVgLjEivEM7reItd3KfW-1ss-tLmIxkhvGutNY50b623jPHG-W7uyra9-_U_UDC53wCRnmro30YX057jgSGFOvwCHTILE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>961171905</pqid></control><display><type>article</type><title>Dietary flavonoid intakes and risk of type 2 diabetes in US men and women</title><source>ScienceDirect Journals</source><source>Medical Journals</source><creator>WEDICK, Nicole M ; AN PAN ; CASSIDY, Aedín ; RIMM, Eric B ; SAMPSON, Laura ; ROSNER, Bernard ; WILLETT, Walter ; HU, Frank B ; QI SUN ; DAM, Rob M.van</creator><creatorcontrib>WEDICK, Nicole M ; AN PAN ; CASSIDY, Aedín ; RIMM, Eric B ; SAMPSON, Laura ; ROSNER, Bernard ; WILLETT, Walter ; HU, Frank B ; QI SUN ; DAM, Rob M.van</creatorcontrib><description>Data from mechanistic studies support a beneficial effect of specific flavonoids on insulin sensitivity. However, few studies have evaluated the relation between intakes of different flavonoid subclasses and type 2 diabetes.
The objective was to evaluate whether dietary intakes of major flavonoid subclasses (ie, flavonols, flavones, flavanones, flavan-3-ols, and anthocyanins) are associated with the risk of type 2 diabetes in US adults.
We followed up a total of 70,359 women in the Nurses' Health Study (NHS; 1984-2008), 89,201 women in the NHS II (1991-2007), and 41,334 men in the Health Professionals Follow-Up Study (1986-2006) who were free of diabetes, cardiovascular disease, and cancer at baseline.
During 3,645,585 person-years of follow-up, we documented 12,611 incident cases of type 2 diabetes. Higher intakes of anthocyanins were significantly associated with a lower risk of type 2 diabetes (pooled HR for the 3 cohorts from a comparison of extreme quintiles: 0.85; 95% CI: 0.80, 0.91; P-trend < 0.001) after multivariate adjustment for age, BMI, and lifestyle and dietary factors. Consumption of anthocyanin-rich foods, particularly blueberries (pooled HR: 0.77 from a comparison of ≥2 servings/wk with <1 serving/mo; 95% CI: 0.68, 0.87; P-trend < 0.001) and apples/pears (pooled HR: 0.77 from a comparison of ≥5 servings/wk with <1 serving/mo; 95% CI: 0.65, 0.83; P-trend < 0.001), was also associated with a lower risk of type 2 diabetes. No significant associations were found for total flavonoid intake or other flavonoid subclasses.
A higher consumption of anthocyanins and anthocyanin-rich fruit was associated with a lower risk of type 2 diabetes.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.3945/ajcn.111.028894</identifier><identifier>PMID: 22357723</identifier><identifier>CODEN: AJCNAC</identifier><language>eng</language><publisher>Bethesda, MD: American Society for Nutrition</publisher><subject>Adult ; Aged ; Anthocyanins - administration & dosage ; Anthocyanins - analysis ; Biological and medical sciences ; Blueberry Plants - chemistry ; Cohort Studies ; Diabetes ; Diabetes Mellitus, Type 2 - etiology ; Diabetes Mellitus, Type 2 - prevention & control ; Diet ; Feeding. Feeding behavior ; Female ; Flavonoids - administration & dosage ; Flavonoids - analysis ; Follow-Up Studies ; Fruit - chemistry ; Fundamental and applied biological sciences. Psychology ; Humans ; Incidence ; Insulin ; Male ; Malus - chemistry ; Middle Aged ; Nutrition ; Polyphenols ; Prospective Studies ; Pyrus - chemistry ; Risk ; United States - epidemiology ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>The American journal of clinical nutrition, 2012-04, Vol.95 (4), p.925-933</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright American Society for Clinical Nutrition, Inc. Apr 1, 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-b3ac108844ebfe186c45fab5222026a0496b21949d16db355c39a5abdbbf845f3</citedby><cites>FETCH-LOGICAL-c440t-b3ac108844ebfe186c45fab5222026a0496b21949d16db355c39a5abdbbf845f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25650915$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22357723$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WEDICK, Nicole M</creatorcontrib><creatorcontrib>AN PAN</creatorcontrib><creatorcontrib>CASSIDY, Aedín</creatorcontrib><creatorcontrib>RIMM, Eric B</creatorcontrib><creatorcontrib>SAMPSON, Laura</creatorcontrib><creatorcontrib>ROSNER, Bernard</creatorcontrib><creatorcontrib>WILLETT, Walter</creatorcontrib><creatorcontrib>HU, Frank B</creatorcontrib><creatorcontrib>QI SUN</creatorcontrib><creatorcontrib>DAM, Rob M.van</creatorcontrib><title>Dietary flavonoid intakes and risk of type 2 diabetes in US men and women</title><title>The American journal of clinical nutrition</title><addtitle>Am J Clin Nutr</addtitle><description>Data from mechanistic studies support a beneficial effect of specific flavonoids on insulin sensitivity. However, few studies have evaluated the relation between intakes of different flavonoid subclasses and type 2 diabetes.
The objective was to evaluate whether dietary intakes of major flavonoid subclasses (ie, flavonols, flavones, flavanones, flavan-3-ols, and anthocyanins) are associated with the risk of type 2 diabetes in US adults.
We followed up a total of 70,359 women in the Nurses' Health Study (NHS; 1984-2008), 89,201 women in the NHS II (1991-2007), and 41,334 men in the Health Professionals Follow-Up Study (1986-2006) who were free of diabetes, cardiovascular disease, and cancer at baseline.
During 3,645,585 person-years of follow-up, we documented 12,611 incident cases of type 2 diabetes. Higher intakes of anthocyanins were significantly associated with a lower risk of type 2 diabetes (pooled HR for the 3 cohorts from a comparison of extreme quintiles: 0.85; 95% CI: 0.80, 0.91; P-trend < 0.001) after multivariate adjustment for age, BMI, and lifestyle and dietary factors. Consumption of anthocyanin-rich foods, particularly blueberries (pooled HR: 0.77 from a comparison of ≥2 servings/wk with <1 serving/mo; 95% CI: 0.68, 0.87; P-trend < 0.001) and apples/pears (pooled HR: 0.77 from a comparison of ≥5 servings/wk with <1 serving/mo; 95% CI: 0.65, 0.83; P-trend < 0.001), was also associated with a lower risk of type 2 diabetes. No significant associations were found for total flavonoid intake or other flavonoid subclasses.
A higher consumption of anthocyanins and anthocyanin-rich fruit was associated with a lower risk of type 2 diabetes.</description><subject>Adult</subject><subject>Aged</subject><subject>Anthocyanins - administration & dosage</subject><subject>Anthocyanins - analysis</subject><subject>Biological and medical sciences</subject><subject>Blueberry Plants - chemistry</subject><subject>Cohort Studies</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - etiology</subject><subject>Diabetes Mellitus, Type 2 - prevention & control</subject><subject>Diet</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Flavonoids - administration & dosage</subject><subject>Flavonoids - analysis</subject><subject>Follow-Up Studies</subject><subject>Fruit - chemistry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Incidence</subject><subject>Insulin</subject><subject>Male</subject><subject>Malus - chemistry</subject><subject>Middle Aged</subject><subject>Nutrition</subject><subject>Polyphenols</subject><subject>Prospective Studies</subject><subject>Pyrus - chemistry</subject><subject>Risk</subject><subject>United States - epidemiology</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNpd0E1LwzAYwPEgipsvZ28SBPHUmfcmR5lvA8GDeg5JmkK2Np1Np-zbm7mp4CmB_J6H8AfgDKMJVYxfm7mLE4zxBBEpFdsDY6yoLChB5T4YI4RIobDgI3CU0hwhTJgUh2BECOVlSegYzG6DH0y_hnVjPrrYhQqGOJiFT9DECvYhLWBXw2G99JDAKhjrh_wWInx7ga2P3-qzy7cTcFCbJvnT3XkM3u7vXqePxdPzw2x681Q4xtBQWGocRlIy5m3tsRSO8dpYTghBRBjElLAEK6YqLCpLOXdUGW5sZW0tM6XH4Gq7d9l37yufBt2G5HzTmOi7VdKKMiJkWaIsL_7JebfqY_6cVgLjEivEM7reItd3KfW-1ss-tLmIxkhvGutNY50b623jPHG-W7uyra9-_U_UDC53wCRnmro30YX057jgSGFOvwCHTILE</recordid><startdate>20120401</startdate><enddate>20120401</enddate><creator>WEDICK, Nicole M</creator><creator>AN PAN</creator><creator>CASSIDY, Aedín</creator><creator>RIMM, Eric B</creator><creator>SAMPSON, Laura</creator><creator>ROSNER, Bernard</creator><creator>WILLETT, Walter</creator><creator>HU, Frank B</creator><creator>QI SUN</creator><creator>DAM, Rob M.van</creator><general>American Society for Nutrition</general><general>American Society for Clinical Nutrition, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T7</scope><scope>7TS</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20120401</creationdate><title>Dietary flavonoid intakes and risk of type 2 diabetes in US men and women</title><author>WEDICK, Nicole M ; AN PAN ; CASSIDY, Aedín ; RIMM, Eric B ; SAMPSON, Laura ; ROSNER, Bernard ; WILLETT, Walter ; HU, Frank B ; QI SUN ; DAM, Rob M.van</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-b3ac108844ebfe186c45fab5222026a0496b21949d16db355c39a5abdbbf845f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anthocyanins - administration & dosage</topic><topic>Anthocyanins - analysis</topic><topic>Biological and medical sciences</topic><topic>Blueberry Plants - chemistry</topic><topic>Cohort Studies</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - etiology</topic><topic>Diabetes Mellitus, Type 2 - prevention & control</topic><topic>Diet</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Flavonoids - administration & dosage</topic><topic>Flavonoids - analysis</topic><topic>Follow-Up Studies</topic><topic>Fruit - chemistry</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Incidence</topic><topic>Insulin</topic><topic>Male</topic><topic>Malus - chemistry</topic><topic>Middle Aged</topic><topic>Nutrition</topic><topic>Polyphenols</topic><topic>Prospective Studies</topic><topic>Pyrus - chemistry</topic><topic>Risk</topic><topic>United States - epidemiology</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WEDICK, Nicole M</creatorcontrib><creatorcontrib>AN PAN</creatorcontrib><creatorcontrib>CASSIDY, Aedín</creatorcontrib><creatorcontrib>RIMM, Eric B</creatorcontrib><creatorcontrib>SAMPSON, Laura</creatorcontrib><creatorcontrib>ROSNER, Bernard</creatorcontrib><creatorcontrib>WILLETT, Walter</creatorcontrib><creatorcontrib>HU, Frank B</creatorcontrib><creatorcontrib>QI SUN</creatorcontrib><creatorcontrib>DAM, Rob M.van</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WEDICK, Nicole M</au><au>AN PAN</au><au>CASSIDY, Aedín</au><au>RIMM, Eric B</au><au>SAMPSON, Laura</au><au>ROSNER, Bernard</au><au>WILLETT, Walter</au><au>HU, Frank B</au><au>QI SUN</au><au>DAM, Rob M.van</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary flavonoid intakes and risk of type 2 diabetes in US men and women</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>2012-04-01</date><risdate>2012</risdate><volume>95</volume><issue>4</issue><spage>925</spage><epage>933</epage><pages>925-933</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><coden>AJCNAC</coden><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Data from mechanistic studies support a beneficial effect of specific flavonoids on insulin sensitivity. However, few studies have evaluated the relation between intakes of different flavonoid subclasses and type 2 diabetes.
The objective was to evaluate whether dietary intakes of major flavonoid subclasses (ie, flavonols, flavones, flavanones, flavan-3-ols, and anthocyanins) are associated with the risk of type 2 diabetes in US adults.
We followed up a total of 70,359 women in the Nurses' Health Study (NHS; 1984-2008), 89,201 women in the NHS II (1991-2007), and 41,334 men in the Health Professionals Follow-Up Study (1986-2006) who were free of diabetes, cardiovascular disease, and cancer at baseline.
During 3,645,585 person-years of follow-up, we documented 12,611 incident cases of type 2 diabetes. Higher intakes of anthocyanins were significantly associated with a lower risk of type 2 diabetes (pooled HR for the 3 cohorts from a comparison of extreme quintiles: 0.85; 95% CI: 0.80, 0.91; P-trend < 0.001) after multivariate adjustment for age, BMI, and lifestyle and dietary factors. Consumption of anthocyanin-rich foods, particularly blueberries (pooled HR: 0.77 from a comparison of ≥2 servings/wk with <1 serving/mo; 95% CI: 0.68, 0.87; P-trend < 0.001) and apples/pears (pooled HR: 0.77 from a comparison of ≥5 servings/wk with <1 serving/mo; 95% CI: 0.65, 0.83; P-trend < 0.001), was also associated with a lower risk of type 2 diabetes. No significant associations were found for total flavonoid intake or other flavonoid subclasses.
A higher consumption of anthocyanins and anthocyanin-rich fruit was associated with a lower risk of type 2 diabetes.</abstract><cop>Bethesda, MD</cop><pub>American Society for Nutrition</pub><pmid>22357723</pmid><doi>10.3945/ajcn.111.028894</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9165 |
| ispartof | The American journal of clinical nutrition, 2012-04, Vol.95 (4), p.925-933 |
| issn | 0002-9165 1938-3207 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_934268770 |
| source | ScienceDirect Journals; Medical Journals |
| subjects | Adult Aged Anthocyanins - administration & dosage Anthocyanins - analysis Biological and medical sciences Blueberry Plants - chemistry Cohort Studies Diabetes Diabetes Mellitus, Type 2 - etiology Diabetes Mellitus, Type 2 - prevention & control Diet Feeding. Feeding behavior Female Flavonoids - administration & dosage Flavonoids - analysis Follow-Up Studies Fruit - chemistry Fundamental and applied biological sciences. Psychology Humans Incidence Insulin Male Malus - chemistry Middle Aged Nutrition Polyphenols Prospective Studies Pyrus - chemistry Risk United States - epidemiology Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Dietary flavonoid intakes and risk of type 2 diabetes in US men and women |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-22T04%3A25%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dietary%20flavonoid%20intakes%20and%20risk%20of%20type%202%20diabetes%20in%20US%20men%20and%20women&rft.jtitle=The%20American%20journal%20of%20clinical%20nutrition&rft.au=WEDICK,%20Nicole%20M&rft.date=2012-04-01&rft.volume=95&rft.issue=4&rft.spage=925&rft.epage=933&rft.pages=925-933&rft.issn=0002-9165&rft.eissn=1938-3207&rft.coden=AJCNAC&rft_id=info:doi/10.3945/ajcn.111.028894&rft_dat=%3Cproquest_cross%3E934268770%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c440t-b3ac108844ebfe186c45fab5222026a0496b21949d16db355c39a5abdbbf845f3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=961171905&rft_id=info:pmid/22357723&rfr_iscdi=true |