Dietary flavonoid intakes and risk of type 2 diabetes in US men and women

Data from mechanistic studies support a beneficial effect of specific flavonoids on insulin sensitivity. However, few studies have evaluated the relation between intakes of different flavonoid subclasses and type 2 diabetes. The objective was to evaluate whether dietary intakes of major flavonoid su...

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Bibliographic Details
Published in:The American journal of clinical nutrition 2012-04, Vol.95 (4), p.925-933
Main Authors: WEDICK, Nicole M, AN PAN, CASSIDY, Aedín, RIMM, Eric B, SAMPSON, Laura, ROSNER, Bernard, WILLETT, Walter, HU, Frank B, QI SUN, DAM, Rob M.van
Format: Article
Language:English
Subjects:
Adult
Aged
Anthocyanins - administration & dosage
Anthocyanins - analysis
Biological and medical sciences
Blueberry Plants - chemistry
Cohort Studies
Diabetes
Diabetes Mellitus, Type 2 - etiology
Diabetes Mellitus, Type 2 - prevention & control
Diet
Feeding. Feeding behavior
Female
Flavonoids - administration & dosage
Flavonoids - analysis
Follow-Up Studies
Fruit - chemistry
Fundamental and applied biological sciences. Psychology
Humans
Incidence
Insulin
Male
Malus - chemistry
Middle Aged
Nutrition
Polyphenols
Prospective Studies
Pyrus - chemistry
Risk
United States - epidemiology
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:Data from mechanistic studies support a beneficial effect of specific flavonoids on insulin sensitivity. However, few studies have evaluated the relation between intakes of different flavonoid subclasses and type 2 diabetes. The objective was to evaluate whether dietary intakes of major flavonoid subclasses (ie, flavonols, flavones, flavanones, flavan-3-ols, and anthocyanins) are associated with the risk of type 2 diabetes in US adults. We followed up a total of 70,359 women in the Nurses' Health Study (NHS; 1984-2008), 89,201 women in the NHS II (1991-2007), and 41,334 men in the Health Professionals Follow-Up Study (1986-2006) who were free of diabetes, cardiovascular disease, and cancer at baseline. During 3,645,585 person-years of follow-up, we documented 12,611 incident cases of type 2 diabetes. Higher intakes of anthocyanins were significantly associated with a lower risk of type 2 diabetes (pooled HR for the 3 cohorts from a comparison of extreme quintiles: 0.85; 95% CI: 0.80, 0.91; P-trend < 0.001) after multivariate adjustment for age, BMI, and lifestyle and dietary factors. Consumption of anthocyanin-rich foods, particularly blueberries (pooled HR: 0.77 from a comparison of ≥2 servings/wk with
ISSN:0002-9165
1938-3207
DOI:10.3945/ajcn.111.028894