Epidemiology of Escherichia coli, Klebsiella Species, and Proteus mirabilis Strains Producing Extended-Spectrum β-Lactamases From Clinical Samples in the Kinki Region of Japan

In the present study, nonduplicate, clinical isolates of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli, Klebsiella spp, and Proteus mirabilis were collected during a 10-year period from 2000 to 2009 at several hospitals in the Kinki region, Japan. The detection rate of E coli marke...

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Published in:American journal of clinical pathology 2012-04, Vol.137 (4), p.620-626
Main Authors: NAKAMURA, Tatsuya, KOMATSU, Masaru, SATOH, Kaori, TODA, Hirofumi, TOYOKAWA, Masahiro, NISHI, Isao, SAKAMOTO, Masako, AKAGI, Masahiro, NAKAI, Isako, KOFUKU, Tomomi, ORITA, Tamaki, WADA, Yasunao, YAMASAKI, Katsutoshi, ZIKIMOTO, Takuya, KOIKE, Chihiro, KINOSHITA, Shohiro, HIRAI, Itaru, TAKAHASHI, Hakuo, MATSUURA, Nariaki, YAMAMOTO, Yoshimasa, FUKUDA, Saori, MIYAMOTO, Yugo, HIGUCHI, Takeshi, ONO, Tamotsu, NISHIO, Hisaaki, SUEYOSHI, Noriyuki, KIDA, Kenji
Format: Article
Language:English
Subjects:
Bacterial Typing Techniques
beta-Lactamases - genetics
Biological and medical sciences
DNA, Bacterial - genetics
Escherichia coli - genetics
Escherichia coli - isolation & purification
Escherichia coli Infections - epidemiology
Escherichia coli Infections - genetics
Escherichia coli Infections - microbiology
Humans
Investigative techniques, diagnostic techniques (general aspects)
Japan - epidemiology
Klebsiella - genetics
Klebsiella - isolation & purification
Klebsiella Infections - epidemiology
Klebsiella Infections - genetics
Klebsiella Infections - microbiology
Medical sciences
Molecular Epidemiology
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Proteus Infections - epidemiology
Proteus Infections - genetics
Proteus Infections - microbiology
Proteus mirabilis - genetics
Proteus mirabilis - isolation & purification
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Summary:In the present study, nonduplicate, clinical isolates of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli, Klebsiella spp, and Proteus mirabilis were collected during a 10-year period from 2000 to 2009 at several hospitals in the Kinki region, Japan. The detection rate of E coli markedly increased from 0.24% to 7.25%. The detection rate of Klebsiella pneumoniae increased from 0% to 2.44% and that of P mirabilis from 6.97% to 12.85%. The most frequently detected genotypes were the CTX-M9 group for E coli, the CTX-M2 group for K pneumoniae, and the CTX-M2 group for P mirabilis. E coli clone O25:H4-ST131 producing CTX-M-15, which is spreading worldwide, was first detected in 2007. The most common replicon type of E coli was the IncF type, particularly FIB, detected in 466 strains (69.7%). Of the K pneumoniae strains, 47 (55.3%) were of the IncN type; 77 P mirabilis strains (96.3%) were of the IncT type. In the future, the surveillance of various resistant bacteria, mainly ESBL-producing Enterobacteriaceae, should be expanded to prevent their spread.
ISSN:0002-9173
1943-7722
DOI:10.1309/AJCP48PDVKWQOXEZ