Microvesicles in Health and Disease

Microvesicles (or MVs) are plasma membrane-derived vesicles released from most eukaryotic cells constitutively during early apoptosis or at higher levels after chemical or physical stress conditions. This review looks at some of the functions of MVs in terms of intercellular communication and ensuan...

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Bibliographic Details
Published in:Archivum Immunologiae et Therapiae Experimentalis 2012-04, Vol.60 (2), p.107-121
Main Authors: Inal, Jameel M., Ansa-Addo, Ephraim A., Stratton, Dan, Kholia, Sharad, Antwi-Baffour, Samuel S., Jorfi, Samireh, Lange, Sigrun
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Autoimmune Diseases - metabolism
Autoimmune Diseases - pathology
Biological Transport
Biomedical and Life Sciences
Biomedicine
Cell Communication
Cell Transformation, Neoplastic - pathology
Cell Transformation, Neoplastic - ultrastructure
Cell-Derived Microparticles - metabolism
Cell-Derived Microparticles - ultrastructure
Humans
Immunology
Infection - metabolism
Infection - pathology
Neoplasms - metabolism
Neoplasms - pathology
Pharmacology/Toxicology
Review
Signal Transduction
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Summary:Microvesicles (or MVs) are plasma membrane-derived vesicles released from most eukaryotic cells constitutively during early apoptosis or at higher levels after chemical or physical stress conditions. This review looks at some of the functions of MVs in terms of intercellular communication and ensuant signal transduction, including the transport of proteins (unconventional protein export) as well as of mRNA and microRNA. MVs also have roles in membrane repair, the removal of misfolded proteins, and in the control of apoptosis. We also discuss the role MVs have been shown to have in invasive growth and metastasis as well as in hypoxia in tumours and cerebral ischaemia. The association of MVs in infectious and autoimmune disease is also summarised together with their possible use as therapeutic agents.
ISSN:0004-069X
1661-4917
DOI:10.1007/s00005-012-0165-2