Plasticizers excreted in urine: indication of autologous blood transfusion in sports

BACKGROUND: Misuse of autologous blood transfusions in sports remains undetectable. The metabolites of the plasticizer di‐(2‐ethylhexyl)phthalate (DEHP) were recently proposed as markers of blood transfusion, based on high urinary concentrations of these compounds observed in patients subjected to b...

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Bibliographic Details
Published in:Transfusion (Philadelphia, Pa.) Pa.), 2012-03, Vol.52 (3), p.647-657
Main Authors: Monfort, Núria, Ventura, Rosa, Platen, Petra, Hinrichs, Timo, Brixius, Klara, Schänzer, Wilhelm, Thevis, Mario, Geyer, Hans, Segura, Jordi
Format: Article
Language:English
Subjects:
Adult
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Blood Transfusion, Autologous
Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis
Diethylhexyl Phthalate - analogs & derivatives
Diethylhexyl Phthalate - analysis
Diethylhexyl Phthalate - urine
Doping in Sports - methods
Doping in Sports - prevention & control
Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care
Female
Humans
Intensive care medicine
Male
Medical sciences
Phthalic Acids - analysis
Phthalic Acids - urine
Plasticizers - analysis
Plasticizers - pharmacokinetics
Specific Gravity
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
Urine - chemistry
Young Adult
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Summary:BACKGROUND: Misuse of autologous blood transfusions in sports remains undetectable. The metabolites of the plasticizer di‐(2‐ethylhexyl)phthalate (DEHP) were recently proposed as markers of blood transfusion, based on high urinary concentrations of these compounds observed in patients subjected to blood transfusion. This study evaluates DEHP metabolites in urine for detecting autologous blood transfusion. STUDY DESIGN AND METHODS: One blood bag was drawn from moderately trained subjects and the red blood cells (RBCs) were reinfused after different storage periods. Group 1 (12 subjects) was reinfused after 14 days, and Group 2 (13 subjects), after 28 days of storage. Urine samples were collected before and after reinfusion for determination of the concentrations of three DEHP metabolites, mono‐(2‐ethylhexyl)phthalate, mono‐(2‐ethyl‐5‐hydroxyhexyl)phthalate, and mono‐(2‐ethyl‐5‐oxohexyl)phthalate. RESULTS: Concentrations of DEHP metabolites on the days before reinfusion were in agreement with those described after common environmental exposure. A few hours after the reinfusion a significant increase was observed for all metabolites in all volunteers. Concentrations 1 day later were still higher (p 
ISSN:0041-1132
1537-2995
DOI:10.1111/j.1537-2995.2011.03331.x