In Vitro Blockade of Adhesion of Breast Cancer Cells to Endothelial Cells Using Anti-inflammatory Drugs

Increasing evidence suggests that a pro-inflammatory microenvironment affects distant metastasis of breast cancer cells, in particular by favoring tumor cell adhesion to endothelium. The aim of this study was to investigate the potential of different anti-inflammatory drugs to inhibit this effect in...

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Bibliographic Details
Published in:Anticancer research 2012-03, Vol.32 (3), p.767-771
Main Authors: BISCHOFS, Esther, LUBS, Daniel, FRITZSCHE, Friederike, MEYER, Anne-Sophie, BRUCKNER, Thomas, SOHN, Christof, EICHBAUM, Michael H. R
Format: Article
Language:English
Subjects:
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Biological and medical sciences
Breast Neoplasms - pathology
Cell Adhesion - drug effects
Cell Line, Tumor
Endothelium, Vascular - drug effects
Endothelium, Vascular - pathology
Female
Gynecology. Andrology. Obstetrics
Humans
In Vitro Techniques
Mammary gland diseases
Medical sciences
Microscopy, Fluorescence
Tumors
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Summary:Increasing evidence suggests that a pro-inflammatory microenvironment affects distant metastasis of breast cancer cells, in particular by favoring tumor cell adhesion to endothelium. The aim of this study was to investigate the potential of different anti-inflammatory drugs to inhibit this effect in vitro. Breast cancer cells from the metastatic cell line KM22 were incubated with activated Human umbilical vein endothelial cells (HUVECs). Tumor cell adhesion was quantified by fluorescence microscopy. The anti-inflammatory drugs ibuprofen, aspirin (acetylsalicylic acid), diclofenac, and dexamethasone were used as inhibiting agents. Aspirin and dexamethasone significantly reduced breast cancer cell adhesion to HUVECs (20.3%, p
ISSN:0250-7005
1791-7530