Antiplasmodial indole alkaloids from Leuconotis griffithii

A new indole alkaloid, leucoridine A N -oxide ( 1 ), consisting of two units of a strychnan type of skeleton, was isolated from the leaves of Leuconotis griffithii . Its structure was elucidated by various spectroscopic means such as NMR and MS, and also by chemical means. Antiplasmodial activity ag...

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Bibliographic Details
Published in:Journal of natural medicines 2012-04, Vol.66 (2), p.350-353
Main Authors: Nugroho, Alfarius E., Hirasawa, Yusuke, Piow, Wong Chin, Kaneda, Toshio, Hadi, A. Hamid A., Shirota, Osamu, Ekasari, Wiwied, Widyawaruyanti, Aty, Morita, Hiroshi
Format: Article
Language:English
Subjects:
Antimalarials - chemistry
Antimalarials - pharmacology
Apocynaceae - chemistry
Biomedical and Life Sciences
Biomedicine
Complementary & Alternative Medicine
Indole Alkaloids - chemistry
Indole Alkaloids - pharmacology
Magnetic Resonance Spectroscopy
Medicinal Chemistry
Molecular Structure
Pharmacology/Toxicology
Pharmacy
Plant Extracts - chemistry
Plant Extracts - pharmacology
Plant Sciences
Plasmodium falciparum - drug effects
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Summary:A new indole alkaloid, leucoridine A N -oxide ( 1 ), consisting of two units of a strychnan type of skeleton, was isolated from the leaves of Leuconotis griffithii . Its structure was elucidated by various spectroscopic means such as NMR and MS, and also by chemical means. Antiplasmodial activity against Plasmodium falciparum 3D7 of indole alkaloids isolated from L. griffithii was investigated.
ISSN:1340-3443
1861-0293
DOI:10.1007/s11418-011-0574-2