Antifungal Susceptibility and Virulence Attributes of Bloodstream Isolates of Candida from Hong Kong and Finland

Candida bloodstream infection has dramatically increased in the last decade due to the growing number of immunocompromised populations worldwide. In this study, we evaluated the antifungal susceptibility profiles and virulence attributes of Candida bloodstream isolates (CBIs) derived from Hong Kong...

Full description

Saved in:
Bibliographic Details
Published in:Mycopathologia (1975) 2011-11, Vol.172 (5), p.389-395
Main Authors: Seneviratne, C. J., Wong, S. S. W., Yuen, K. Y., Meurman, J. H., Pärnänen, P., Vaara, M., Samaranayake, L. P.
Format: Article
Language:English
Subjects:
Amphotericin B
Amphotericin B - pharmacology
Antifungal agents
Antifungal Agents - pharmacology
Antiparasitic agents
azoles
Biomedical and Life Sciences
Candida
Candida - drug effects
Candida - isolation & purification
Candida - pathogenicity
Candidemia
Candidemia - microbiology
Caspofungin
Data processing
Dentistry
Drug Resistance, Fungal
Echinocandins - pharmacology
Eukaryotic Microbiology
Evolution
Experiments
Finland
fluconazole
Fluconazole - pharmacology
Flucytosine - pharmacology
Health aspects
Hemolysin Proteins - metabolism
Hong Kong
Humans
Infection
Itraconazole
Itraconazole - pharmacology
Ketoconazole
Ketoconazole - pharmacology
Life Sciences
Lipopeptides
Medical Microbiology
Microbial Ecology
Microbial Sensitivity Tests
Microbiology
Nosocomial infections
Peptide Hydrolases - metabolism
Plant Sciences
Proteinase
Pyrimidines - pharmacology
Toy industry
Triazoles - pharmacology
Virulence
Virulence Factors - metabolism
Voriconazole
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Candida bloodstream infection has dramatically increased in the last decade due to the growing number of immunocompromised populations worldwide. In this study, we evaluated the antifungal susceptibility profiles and virulence attributes of Candida bloodstream isolates (CBIs) derived from Hong Kong and Finland, information which are vital for devising empirical clinical strategies. Susceptibility testing of a wide range of antifungals including fluconazole, itraconazole, voriconazole, ketoconazole, 5-fluorocytosine, amphotericin B and caspofungin was performed. Haemolytic activity and secretion of proteinase of CBIs were also examined. All CBIs derived from Hong Kong were susceptible to all the antifungals tested whilst some CBIs from Finland were resistant to azoles and caspofungin. C. albicans , C. glabrata and C. tropicalis showed higher haemolytic activity whereas C. parapsilosis and C. guilliermondii were non-haemolytic in general. Proteinase activity of the Finland C. albicans isolates was significantly higher than the Hong Kong isolates. Our data provide a glimpse of the possible evolutionary changes in pathogenic potential of Candida that may be occurring in different regions of the world. Therefore, continuous surveillance and availability of local data should be taken into consideration when treating candidemia patients.
ISSN:0301-486X
1573-0832
DOI:10.1007/s11046-011-9444-4