Peroxidase-like activity of water-soluble cupric oxide nanoparticles and its analytical application for detection of hydrogen peroxide and glucose

Water-soluble cupric oxide nanoparticles are fabricated via a quick-precipitation method and used as peroxidase mimetics for ultrasensitive detection of hydrogen peroxide and glucose. The water-soluble CuO nanoparticles show much higher catalytic activity than that of commercial CuO nanoparticles du...

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Bibliographic Details
Published in:Analyst (London) 2012-04, Vol.137 (7), p.1706-1712
Main Authors: WEI CHEN, JUAN CHEN, FENG, Ye-Bin, LEI HONG, CHEN, Qi-Ying, WU, Ling-Feng, LIN, Xin-Hua, XIA, Xing-Hua
Format: Article
Language:English
Subjects:
Analytical chemistry
Applied sciences
Chemistry
Colorimetry
Copper - chemistry
Environmental chemistry
Exact sciences and technology
Global environmental pollution
Glucose
Glucose - analysis
Hydrogen peroxide
Hydrogen Peroxide - analysis
Mathematical analysis
Metal Nanoparticles - chemistry
Microscopy, Electron, Transmission
Nanoparticles
Oxides
Peroxidase - chemistry
Phenol
Pollution
Solubility
Spectrometric and optical methods
Water - chemistry
X-Ray Diffraction
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Summary:Water-soluble cupric oxide nanoparticles are fabricated via a quick-precipitation method and used as peroxidase mimetics for ultrasensitive detection of hydrogen peroxide and glucose. The water-soluble CuO nanoparticles show much higher catalytic activity than that of commercial CuO nanoparticles due to their higher affinity to hydrogen peroxide. In addition, the as-prepared CuO nanoparticles are stable over a wide range of pH and temperature. This excellent stability in the form of aqueous colloidal suspensions makes the application of the water-soluble CuO nanoparticles easier in aqueous systems. A colorimetric assay for hydrogen peroxide and glucose has been established based on the catalytic oxidation of phenol coupled with 4-amino-atipyrine by the action of hydrogen peroxide. This analytical platform not only confirms the intrinsic peroxidase-like activity of the water-soluble cupric oxide nanoparticles, but also shows its great potential applications in environmental chemistry, biotechnology and medicine.
ISSN:0003-2654
1364-5528
DOI:10.1039/c2an35072f