A systematic approach to determine optimal composition of gel used in radiation therapy

The design of experiment was used to find the optimal composition of N-isopropyl acrylamide (NIPAM) gel. Optical computed tomography was used to scan the polymer gel dosimeter, which was irradiated from 0 to 20 Gy. The study was conducted following a statistical method using a two-level fractional f...

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Bibliographic Details
Published in:Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment Accelerators, spectrometers, detectors and associated equipment, 2011-10, Vol.652 (1), p.783-785
Main Authors: Chang, Yuan-Jen, Hsieh, Bor-Tsung, Liang, Ji-An
Format: Article
Language:English
Subjects:
Design of experiment
Detectors
Irradiation
Linearity
Mathematical analysis
Mathematical models
NIPAM gel
Optical CT
Optimization
Spectrometers
Statistical methods
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Summary:The design of experiment was used to find the optimal composition of N-isopropyl acrylamide (NIPAM) gel. Optical computed tomography was used to scan the polymer gel dosimeter, which was irradiated from 0 to 20 Gy. The study was conducted following a statistical method using a two-level fractional factorial plan involving four variables (gelatin—5% and 6%, NIPAM—3% and 5%, Bis—2.5% and 3%, and THPC—5 and 10 mM). We produced three batches of gels of the same composition to replicate the experiments. Based on the statistical analysis, a regression model was built. The optimal gel composition for the dose range 0–15 Gy with linearity up to 1.000 is as follows: gelatin (5.67%), NIPAM (5%), Bis (2.56%), and THPC (10 mM). The dose response of the NIPAM polymer gel attains stability about 24 h after irradiation and remains stable up to 3 months.
ISSN:0168-9002
1872-9576
DOI:10.1016/j.nima.2010.09.097