Influence of the application area on finite dose permeation in relation to drug type applied

:  For finite dose skin absorption experiments, a homogeneous donor distribution over the skin surface is usually assumed. However, the influence of the surface distribution on skin absorption is still unknown. The aim of this study was to evaluate the influence of the application area on the permea...

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Bibliographic Details
Published in:Experimental dermatology 2012-03, Vol.21 (3), p.233-235
Main Authors: Hahn, Tsambika, Selzer, Dominik, Neumann, Dirk, Kostka, Karl-Heinz, Lehr, Claus-Michael, Schaefer, Ulrich F.
Format: Article
Language:English
Subjects:
Administration, Cutaneous
Biological and medical sciences
caffeine
Caffeine - pharmacokinetics
computational approach
Dermatology
flufenamic acid
Flufenamic Acid - pharmacokinetics
Humans
Medical sciences
Permeability
Skin - metabolism
Skin Absorption - physiology
surface distribution
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Summary::  For finite dose skin absorption experiments, a homogeneous donor distribution over the skin surface is usually assumed. However, the influence of the surface distribution on skin absorption is still unknown. The aim of this study was to evaluate the influence of the application area on the permeation of drugs during finite dose skin absorption experiments in static Franz diffusion cells. Permeation experiments with stained aqueous drug formulations were conducted, and the application area was determined by a suitable, objective, automated computational approach. The permeation of caffeine is strongly dependent on the application area. The variability between single experiments decreased when including the application area. For the lipophilic flufenamic acid, this was not the case. The variability highly increased after inclusion of the application area. Thus, a correction of the area is misleading. In summary, depending on the drug’s physicochemical characteristics, the application area may influence skin absorption.
ISSN:0906-6705
1600-0625
DOI:10.1111/j.1600-0625.2011.01424.x