An Asymmetric Hydroformylation Catalyst that Delivers Branched Aldehydes from Alkyl Alkenes

Surprising selectivity: The first enantioselective hydroformylations of simple alkenes of type RCH2CHCH2 to preferentially deliver the branched aldehyde product have been discovered using a new chiral ligand, named bobphos (see scheme). Established ligands are unselective in this reaction or show a...

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Bibliographic Details
Published in:Angewandte Chemie (International ed.) 2012-03, Vol.51 (10), p.2477-2480
Main Authors: Noonan, Gary M., Fuentes, José A., Cobley, Christopher J., Clarke, Matthew L.
Format: Article
Language:English
Subjects:
Aldehydes
Alkenes
asymmetric hydroformylation
Asymmetry
Branched
carbonylation
Catalysts
Ligands
phosphine-phosphite ligands
regioselectivity
Selectivity
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Summary:Surprising selectivity: The first enantioselective hydroformylations of simple alkenes of type RCH2CHCH2 to preferentially deliver the branched aldehyde product have been discovered using a new chiral ligand, named bobphos (see scheme). Established ligands are unselective in this reaction or show a slight preference towards the linear aldehyde.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201108203