A Synthetic Approach Toward a Self-Regulated Insulin Delivery System

Protein‐free: A hydrogel containing phenylboronate was optimized so as to undergo rapid glucose‐dependent changes in the state of hydration under physiological aqueous conditions. A localized dehydration of the gel surface to form a “skin layer” enabled control of the release of insulin from the gel...

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Bibliographic Details
Published in:Angewandte Chemie (International ed.) 2012-02, Vol.51 (9), p.2124-2128
Main Authors: Matsumoto, Akira, Ishii, Takehiko, Nishida, Junko, Matsumoto, Hiroko, Kataoka, Kazunori, Miyahara, Yuji
Format: Article
Language:English
Subjects:
Animals
Boronic Acids - chemical synthesis
Boronic Acids - chemistry
Boronic Acids - metabolism
Cattle
Control surfaces
Dehydration
Delayed-Action Preparations - chemical synthesis
Delayed-Action Preparations - chemistry
Delayed-Action Preparations - metabolism
Delivery systems
Fluctuation
gels
Glucose
Glucose - metabolism
Hydration
Hydrogel, Polyethylene Glycol Dimethacrylate - chemical synthesis
Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry
Hydrogel, Polyethylene Glycol Dimethacrylate - metabolism
Hydrogels
Hyperglycemia
Insulin
Insulin - administration & dosage
phenylboronates
polymers
skin layer
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Summary:Protein‐free: A hydrogel containing phenylboronate was optimized so as to undergo rapid glucose‐dependent changes in the state of hydration under physiological aqueous conditions. A localized dehydration of the gel surface to form a “skin layer” enabled control of the release of insulin from the gel. This dehydration is induced by fluctuations in the glucose concentration in the range between normo‐ and hyperglycemia.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201106252