Hematopoiesis: A Human Perspective

Despite its complexity, blood is probably the best understood developmental system, largely due to seminal experimentation in the mouse. Clinically, hematopoietic stem cell (HSC) transplantation represents the most widely deployed regenerative therapy, but human HSCs have only been characterized rel...

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Bibliographic Details
Published in:	Cell stem cell 2012-02, Vol.10 (2), p.120-136
Main Authors:	Doulatov, Sergei, Notta, Faiyaz, Laurenti, Elisa, Dick, John E.
Format:	Article
Language:	eng
Subjects:	Animals Biological and medical sciences Cell differentiation, maturation, development, hematopoiesis Cell Lineage Cell physiology Fundamental and applied biological sciences. Psychology Hematopoiesis Hematopoietic Stem Cell Transplantation Hematopoietic Stem Cells - physiology Humans Mice Mice, SCID Models, Animal Molecular and cellular biology Regenerative Medicine - trends
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Summary:	Despite its complexity, blood is probably the best understood developmental system, largely due to seminal experimentation in the mouse. Clinically, hematopoietic stem cell (HSC) transplantation represents the most widely deployed regenerative therapy, but human HSCs have only been characterized relatively recently. The discovery that immune-deficient mice could be engrafted with human cells provided a powerful approach for studying HSCs. We highlight 2 decades of studies focusing on isolation and molecular regulation of human HSCs, therapeutic applications, and early lineage commitment steps, and compare mouse and humanized models to identify both conserved and species-specific mechanisms that will aid future preclinical research.
ISSN:	1934-5909 1875-9777