Synergistic interactions between kainate and mGlu receptors regulate bouton Ca signalling and mossy fibre LTP

It is currently unknown why glutamatergic presynaptic terminals express multiple types of glutamate receptors. We have addressed this question by studying both acute and long-term regulation of mossy fibre function in the hippocampus. We find that inhibition of both mGlu₁ and mGlu₅ receptors togethe...

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Bibliographic Details
Published in:Scientific reports 2011, Vol.1, p.103-103
Main Authors: Nisticò, Robert, Dargan, Sheila L, Amici, Mascia, Collingridge, Graham L, Bortolotto, Zuner A
Format: Article
Language:English
Subjects:
Animals
Calcium Signaling
Cyclic AMP-Dependent Protein Kinases - metabolism
Enzyme Activation
Female
Long-Term Potentiation
Mossy Fibers, Hippocampal - enzymology
Mossy Fibers, Hippocampal - physiology
Presynaptic Terminals - metabolism
Rats
Rats, Wistar
Receptors, Kainic Acid - antagonists & inhibitors
Receptors, Kainic Acid - metabolism
Receptors, Metabotropic Glutamate - antagonists & inhibitors
Receptors, Metabotropic Glutamate - metabolism
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Summary:It is currently unknown why glutamatergic presynaptic terminals express multiple types of glutamate receptors. We have addressed this question by studying both acute and long-term regulation of mossy fibre function in the hippocampus. We find that inhibition of both mGlu₁ and mGlu₅ receptors together can block the induction of mossy fibre LTP. Furthermore, mossy fibre LTP can be induced by the pharmacological activation of either mGlu₁ or mGlu₅ receptors, provided that kainate receptors are also stimulated. Like conventional mossy fibre LTP, chemically-induced mossy fibre LTP (chem-LTPm) depends on Ca²⁺ release from intracellular stores and the activation of PKA. Similar synergistic interactions between mGlu receptors and kainate receptors were observed at the level of Ca²⁺ signalling in individual giant mossy fibre boutons. Thus three distinct glutamate receptors interact, in both an AND and OR gate fashion, to regulate both immediate and long-term presynaptic function in the brain.
ISSN:2045-2322
DOI:10.1038/srep00103