Acute neurocognitive effects of epigallocatechin gallate (EGCG)

Green tea is reported to have wide ranging beneficial health outcomes across epidemiological studies, which have been attributed to its flavonoid content. We investigated whether the flavonoid epigallocatechin gallate (EGCG) modulates brain activity and self-reported mood in a double-blind, placebo...

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Bibliographic Details
Published in:Appetite 2012-04, Vol.58 (2), p.767-770
Main Authors: Scholey, Andrew, Downey, Luke A., Ciorciari, Joseph, Pipingas, Andrew, Nolidin, Karen, Finn, Melissa, Wines, Melissa, Catchlove, Sarah, Terrens, Alirra, Barlow, Emma, Gordon, Leanne, Stough, Con
Format: Article
Language:English
Subjects:
acute effects
Affect - drug effects
Aged
Aged, 80 and over
brain
Brain - drug effects
Brain - physiology
Camellia sinensis - chemistry
Catechin - administration & dosage
Catechin - analogs & derivatives
cognition
Cognition - drug effects
Cross-Over Studies
Double-Blind Method
EEG
EGCG
Electroencephalography
emotions
epidemiological studies
epigallocatechin
Epigallocatechin gallate
Female
Green tea
Humans
Male
Middle Aged
Mood
Placebos
Plant Extracts - administration & dosage
RCT
Tea
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Summary:Green tea is reported to have wide ranging beneficial health outcomes across epidemiological studies, which have been attributed to its flavonoid content. We investigated whether the flavonoid epigallocatechin gallate (EGCG) modulates brain activity and self-reported mood in a double-blind, placebo controlled crossover study. Participants completed baseline assessments of cognitive and cardiovascular functioning, mood and a resting state electroencephalogram (EEG) before and then 120min following administration of 300mg EGCG or matched placebo. EGCG administration was associated with a significant overall increase in alpha, beta and theta activity, also reflected in overall EEG activity, more dominant in midline frontal and central regions, specifically in the frontal gyrus and medial frontal gyrus. In comparison to placebo the EGCG treatment also increased self-rated calmness and reduced self rated stress. This pattern of results suggests that participants in the EGCG condition may have been in a more relaxed and attentive state after consuming EGCG. This is in keeping with the widespread consumption of green tea for its purported relaxing/refreshing properties. The modulation of brain function due to EGCG is deserving of further controlled human studies.
ISSN:0195-6663
1095-8304
DOI:10.1016/j.appet.2011.11.016