Different subtypes of intraductal papillary mucinous neoplasm in the pancreas have distinct pathways to pancreatic cancer progression

Background Intraductal papillary mucinous neoplasm (IPMN) is recognized as a precursor lesion to pancreatic cancer, a unique pathological entity. IPMN has subtypes with different clinical characteristics. However, the molecular mechanisms of cancer progression from IPMN remain largely unknown. In th...

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Bibliographic Details
Published in:Journal of gastroenterology 2012-02, Vol.47 (2), p.203-213
Main Authors: Mohri, Dai, Asaoka, Yoshinari, Ijichi, Hideaki, Miyabayashi, Koji, Kudo, Yotaro, Seto, Motoko, Ohta, Miki, Tada, Motohisa, Tanaka, Yasuo, Ikenoue, Tsuneo, Tateishi, Keisuke, Isayama, Hiroyuki, Kanai, Fumihiko, Fukushima, Noriyoshi, Tada, Minoru, Kawabe, Takao, Omata, Masao, Koike, Kazuhiko
Format: Article
Language:English
Subjects:
Abdominal Surgery
Adenocarcinoma, Mucinous - genetics
Adult
Aged
Biliary Tract
Bone Morphogenetic Proteins - physiology
Cancer
Carcinoma, Pancreatic Ductal - genetics
Carcinoma, Pancreatic Ductal - pathology
Class I Phosphatidylinositol 3-Kinases
Colorectal Surgery
Cyclin-Dependent Kinase Inhibitor p16 - metabolism
Development and progression
Disease Progression
DNA Mutational Analysis
Female
Gastroenterology
Gene Expression Regulation, Neoplastic - genetics
Genetic research
Hepatology
Humans
Immunohistochemistry
Male
Medical colleges
Medicine
Medicine & Public Health
Middle Aged
Oncology, Experimental
Original Article—Liver
Pancreas
Pancreatic cancer
Pancreatic Neoplasms - genetics
Pancreatic Neoplasms - pathology
Phosphatidylinositol 3-Kinases - genetics
Protein Tyrosine Phosphatases - metabolism
Proto-Oncogene Proteins - genetics
Proto-Oncogene Proteins B-raf - genetics
Proto-Oncogene Proteins p21(ras)
ras Proteins - genetics
Signal Transduction - genetics
Smad Proteins - physiology
Surgical Oncology
Tumor proteins
Tumor Suppressor Protein p53 - metabolism
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Summary:Background Intraductal papillary mucinous neoplasm (IPMN) is recognized as a precursor lesion to pancreatic cancer, a unique pathological entity. IPMN has subtypes with different clinical characteristics. However, the molecular mechanisms of cancer progression from IPMN remain largely unknown. In this study we examined the differences in genetic alteration(s) among the IPMN subtypes. Methods Surgically resected IPMNs ( n  = 25) were classified into four subtypes by hematoxylin and eosin (H&E) and mucin immunostaining. Mutations in KRAS , BRAF , and PIK3CA genes and expression of CDKN2A, TP53, SMAD4, phospho-ERK, and phospho-SMAD1/5/8 proteins were examined. Results There were 11 gastric, 11 intestinal, one pancreatobiliary, and two oncocytic types in this study. We then compared the two major subtypes, gastric-type and intestinal-type IPMN. Gastric-type IPMN showed a significantly higher incidence of KRAS mutations (9/11, 81.8%) compared with intestinal type (3/11, 27.3%; p  
ISSN:0944-1174
1435-5922
DOI:10.1007/s00535-011-0482-y