Cancer treatment-induced oral mucositis: a critical review

Abstract Head and neck cancer represents one of the main oncological problems. Its treatment, radiotherapy and chemotherapy leads to mucositis, and other side effects. The authors reviewed high-quality evidence published over the last 25 years on the treatment of cancer treatment-induced oral mucosi...

Full description

Saved in:
Bibliographic Details
Published in:International journal of oral and maxillofacial surgery 2012-02, Vol.41 (2), p.225-238
Main Authors: Rodríguez-Caballero, A, Torres-Lagares, D, Robles-García, M, Pachón-Ibáñez, J, González-Padilla, D, Gutiérrez-Pérez, J.L
Format: Article
Language:English
Subjects:
Antineoplastic Agents - adverse effects
Biological and medical sciences
Chemoradiotherapy - adverse effects
Chemotherapy
Dentistry
Head and Neck Neoplasms - radiotherapy
Head and Neck Neoplasms - therapy
Humans
Medical sciences
Oral cancer
Oral mucositis
Otorhinolaryngology. Stomatology
Prevention
Radiation Injuries - etiology
Radiotherapy
Randomized Controlled Trials as Topic
Stomatitis - etiology
Stomatitis - prevention & control
Stomatitis - therapy
Surgery
Treatment
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Head and neck cancer represents one of the main oncological problems. Its treatment, radiotherapy and chemotherapy leads to mucositis, and other side effects. The authors reviewed high-quality evidence published over the last 25 years on the treatment of cancer treatment-induced oral mucositis. A Medline search for double blind randomized controlled clinical trials between 1985 and 2010 was carried out. The keywords were oral mucositis, radiotherapy, chemotherapy, and head and neck. The different therapeutic approaches found for cancer treatment-induced oral mucositis included: intensive oral hygiene care; use of topical antiseptics and antimicrobial agents; use of anti-inflammatory agents; cytokines and growth factors; locally applied non-pharmacological methods; antioxidants; immune modulators; and homoeopathic agents. To date, no intervention has been able to prevent and treat oral mucositis on its own. It is necessary to combine interventions that act on the different phases of mucositis. It is still unclear which strategies reduce oral mucositis, as there is not enough evidence that describes a treatment with a proven efficiency and is superior to the other treatments for this condition.
ISSN:0901-5027
1399-0020
DOI:10.1016/j.ijom.2011.10.011