Prognostic significance of using solid versus whole tumor size on high-resolution computed tomography for predicting pathologic malignant grade of tumors in clinical stage IA lung adenocarcinoma: A multicenter study

Objectives The present multicenter study compared the usefulness of the solid tumor size with that of the whole tumor size on preoperative high-resolution computed tomography for predicting pathologic high-grade malignancy (positive lymphatic, vascular, or pleural invasion) and the prognosis of clin...

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Published in:The Journal of thoracic and cardiovascular surgery 2012-03, Vol.143 (3), p.607-612
Main Authors: Tsutani, Yasuhiro, MD, PhD, Miyata, Yoshihiro, MD, PhD, Nakayama, Haruhiko, MD, PhD, Okumura, Sakae, MD, PhD, Adachi, Shuji, MD, PhD, Yoshimura, Masahiro, MD, PhD, Okada, Morihito, MD, PhD
Format: Article
Language:English
Subjects:
Adenocarcinoma - diagnostic imaging
Adenocarcinoma - mortality
Adenocarcinoma - pathology
Adenocarcinoma of Lung
Aged
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Cardiology. Vascular system
Cardiothoracic Surgery
Disease-Free Survival
Female
Fluorodeoxyglucose F18
Humans
Japan
Kaplan-Meier Estimate
Logistic Models
Lung Neoplasms - diagnostic imaging
Lung Neoplasms - mortality
Lung Neoplasms - pathology
Male
Medical sciences
Middle Aged
Multimodal Imaging
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Neoplasm Grading
Neoplasm Staging
Pneumology
Positron-Emission Tomography
Predictive Value of Tests
Prognosis
Proportional Hazards Models
Radiopharmaceuticals
Risk Assessment
Risk Factors
Survival Rate
Time Factors
Tomography, X-Ray Computed
Tumor Burden
Tumors
Tumors of the respiratory system and mediastinum
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Summary:Objectives The present multicenter study compared the usefulness of the solid tumor size with that of the whole tumor size on preoperative high-resolution computed tomography for predicting pathologic high-grade malignancy (positive lymphatic, vascular, or pleural invasion) and the prognosis of clinical stage IA lung adenocarcinoma. Methods We performed high-resolution computed tomography and F-18 fluorodeoxyglucose-positron emission tomography/computed tomography before curative surgical resection in 502 patients with clinical stage IA lung adenocarcinoma. The revised maximum standardized uptake values on F-18 fluorodeoxyglucose-positron emission tomography/computed tomography were used to correct interinstitutional discrepancies. The whole and solid tumor sizes on high-resolution computed tomography were then analyzed in relation to surgical results. Results The mean whole and solid tumor size was 1.97 ± 0.59 cm and 1.20 ± 0.88 cm, respectively. The receiver operating characteristics area under the curve for the whole and solid tumor sizes used to identify high-grade malignancy were 0.590 and 0.829, respectively. Multiple logistic regression analyses demonstrated solid tumor size ( P  
ISSN:0022-5223
1097-685X
DOI:10.1016/j.jtcvs.2011.10.037