Incidence, risk factors, and outcome of pneumatosis intestinalis in pediatric stem cell transplant recipients

Background Pneumatosis Intestinalis (PI) is a rare complication following hematopoietic stem cell transplant (HSCT). We sought to assess the incidence, risk factors, and outcome associated with PI. Procedure We retrospectively reviewed the incidence of PI among 178 patients who underwent allogeneic...

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Bibliographic Details
Published in:Pediatric blood & cancer 2012-04, Vol.58 (4), p.616-620
Main Authors: Korhonen, Katrina, Lovvorn III, Harold N., Koyama, Tatsuki, Koehler, Elizabeth, Calder, Cassie, Manes, Becky, Evans, Misty, Bruce, Kathryn, Ho, Richard H., Domm, Jennifer, Frangoul, Haydar
Format: Article
Language:English
Subjects:
Acute Disease
Child
Child, Preschool
Chronic Disease
Female
Graft vs Host Disease - mortality
Graft vs Host Disease - therapy
hematopoietic stem cell transplant
Humans
Incidence
Male
Pneumatosis Cystoides Intestinalis - etiology
Pneumatosis Cystoides Intestinalis - mortality
Pneumatosis Cystoides Intestinalis - therapy
pneumatosis intestinalis
pneumoperitoneum' graft versus host disease
Retrospective Studies
Risk Factors
Stem Cell Transplantation
Time Factors
Transplantation, Homologous
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Summary:Background Pneumatosis Intestinalis (PI) is a rare complication following hematopoietic stem cell transplant (HSCT). We sought to assess the incidence, risk factors, and outcome associated with PI. Procedure We retrospectively reviewed the incidence of PI among 178 patients who underwent allogeneic HSCT between September 1999 and February 2010. Results Eighteen of 178 children (10.1%) who received allogeneic HSCT developed PI at a median of 94 days (range, 11–1169) after transplant. All patients presented with either abdominal pain or distention, and half of the patients had free air on radiographs. Patients who developed PI had a significantly higher proportion of acute (83% vs. 44%, P = 0.002) and chronic graft versus host disease (GVHD; 56% vs. 18%, P 
ISSN:1545-5009
1545-5017
DOI:10.1002/pbc.23242