Inflammatory effects on human lung epithelial cells after exposure to diesel exhaust micron sub particles (PM 1.0) and pollen allergens

Asthma is currently defined as a chronic inflammatory disease of the airway. Several evidence indicate that vehicle emissions in cities is correlated with the allergic respiratory diseases. In the present study, we evaluated in the A549 cells the production and release of IL-4, IL-5 and IL-13 after...

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Bibliographic Details
Published in:Environmental pollution (1987) 2012-02, Vol.161, p.64-69
Main Authors: Mazzarella, G., Esposito, V., Bianco, A., Ferraraccio, F., Prati, M.V., Lucariello, A., Manente, L., Mezzogiorno, A., De Luca, A.
Format: Article
Language:English
Subjects:
Air
Air Pollutants - toxicity
allergens
Allergens - toxicity
Asthma
Biological and medical sciences
Cell Line
cities
emissions
Environmental pollutants toxicology
epithelial cells
Epithelial Cells - drug effects
Epithelial Cells - immunology
Epithelial Cells - metabolism
Humans
IL-13
IL-4
IL-5
immune system
interleukin-13
interleukin-4
interleukin-5
Lung - drug effects
Lung - immunology
Lung - metabolism
Medical sciences
Parietaria
Parietaria officinalis
Particle Size
Particulate Matter - toxicity
pollen
Pollen - toxicity
Sub-micron PM particles
Toxicology
Vehicle Emissions - toxicity
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Summary:Asthma is currently defined as a chronic inflammatory disease of the airway. Several evidence indicate that vehicle emissions in cities is correlated with the allergic respiratory diseases. In the present study, we evaluated in the A549 cells the production and release of IL-4, IL-5 and IL-13 after treatment with sub-micron PM 1.0 particles (PM 1.0), Parietaria officinalis (ALL), and PM 1.0 + ALL together. Our data demonstrated that PM 1.0 + ALL together exhibited the greatest capacity to induce A549 cells to enhance the expression of IL-4 and IL-5 compared with the only PM 1.0 or ALL treatment. Interestingly, IL-13 that is necessary for allergen-induced airway hyper responsiveness, is increased in cells treated with PM 1.0 + ALL together, but is higher expressed when the cells are treated only with the allergen. Our data support the hypothesis that the urban environment damage the acinar lung units and activates cells of the immune system. ► The genetic factors plays a key role in the development of the asthma. ► Its development can only be made in the presence of specific environmental factors. ► We evaluated in the A549 cells the production and release of IL-4, IL-5 and IL-13. ► IL-4, IL-5 and IL-13 expression increased when the A549 cells are treated with PM 1.0 + ALL together. The urban environment with the combination of inhalable air pollution and particulate are able to damage the acinar lung units and are able to activate cells of the immune system.
ISSN:0269-7491
1873-6424
DOI:10.1016/j.envpol.2011.09.046