Inhibition of mTOR by rapamycin in the amygdala or hippocampus impairs formation and reconsolidation of inhibitory avoidance memory

► We examined the role of mTOR in fear memory. ► Rapamycin in the amygdala or hippocampus around training or retrieval impaired memory. ► mTOR in the amygdala and hippocampus is involved in fear memory reconsolidation. Mammalian target of rapamycin (mTOR), a central regulator of protein synthesis in...

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Published in:Neurobiology of learning and memory 2012-01, Vol.97 (1), p.105-112
Main Authors: Jobim, Paulo F.C., Pedroso, Thiago R., Christoff, Raissa R., Werenicz, Aline, Maurmann, Natasha, Reolon, Gustavo K., Roesler, Rafael
Format: Article
Language:English
Subjects:
Amygdala - drug effects
Animal memory
Animals
Avoidance Learning - drug effects
Behavioral psychophysiology
Biological and medical sciences
Brain
Consolidation
Electroshock
Fundamental and applied biological sciences. Psychology
Hippocampus - drug effects
Inhibitory avoidance
Male
Memory - drug effects
mTOR
Neurobiology
Neurons - drug effects
Protein synthesis
Proteins
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rapamycin
Rats
Rats, Wistar
Reconsolidation
Retention (Psychology) - drug effects
Retention (Psychology) - physiology
Rodents
Sirolimus - pharmacology
TOR Serine-Threonine Kinases - antagonists & inhibitors
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Summary:► We examined the role of mTOR in fear memory. ► Rapamycin in the amygdala or hippocampus around training or retrieval impaired memory. ► mTOR in the amygdala and hippocampus is involved in fear memory reconsolidation. Mammalian target of rapamycin (mTOR), a central regulator of protein synthesis in neurons, has been implicated in synaptic plasticity and memory. Here we show that mTOR inhibition by rapamycin in the basolateral amygdala (BLA) or dorsal hippocampus (DH) impairs both formation and reconsolidation of memory for inhibitory avoidance (IA) in rats. Male Wistar rats received bilateral infusions of vehicle or rapamycin into the BLA or DH before or after IA training or retrieval. Memory retention was tested at different time points after drug infusion. Rapamycin impaired long-term IA retention when given before or immediately after training or retrieval into the BLA. When infused into the DH, rapamycin produced memory impairment when given before training or immediately after retrieval. The impairing effects of post-retrieval rapamycin required memory retrieval and were not reversed by a reminder shock. The results provide the first evidence that mTOR in the BLA and DH might play a role in IA memory reconsolidation.
ISSN:1074-7427
1095-9564
DOI:10.1016/j.nlm.2011.10.002