Neonatal follow-up of 995 consecutively born children after embryo biopsy for PGD

BACKGROUND Outcome data on children born after assisted reproduction treatments are important for both patients and health-care providers. The objective of this study was to determine whether embryo biopsy as performed in PGD has an impact on the health of infants up to 2 months of age. METHODS A pr...

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Bibliographic Details
Published in:Human reproduction (Oxford) 2012-01, Vol.27 (1), p.288-293
Main Authors: Desmyttere, S., De Rycke, M., Staessen, C., Liebaers, I., De Schrijver, F., Verpoest, W., Haentjens, P., Bonduelle, Maryse
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biopsy - adverse effects
Biopsy - methods
Birth Weight
Female
Follow-Up Studies
Gynecology. Andrology. Obstetrics
Humans
Infant
Infant, Newborn
Male
Medical sciences
Multivariate Analysis
Pregnancy
Pregnancy Outcome
Preimplantation Diagnosis - adverse effects
Preimplantation Diagnosis - methods
Prospective Studies
Risk
Sperm Injections, Intracytoplasmic - methods
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Summary:BACKGROUND Outcome data on children born after assisted reproduction treatments are important for both patients and health-care providers. The objective of this study was to determine whether embryo biopsy as performed in PGD has an impact on the health of infants up to 2 months of age. METHODS A prospective comparative follow-up study of children born after PGD and children born after ICSI by collecting written reports and performing a physical examination at 2 months was performed. Auxological data at birth and physical findings up to 2 months of age were compared for 995 children consecutively live born after embryo biopsy (1994–2009) and for a control group of 1507 children born after ICSI with embryo transfer on Day 5. RESULTS No differences regarding mean term, prematurity (term
ISSN:0268-1161
1460-2350
DOI:10.1093/humrep/der360