Antimicrobial susceptibility of Helicobacter pylori to six antibiotics currently used in Spain

Background Antibiotic resistance is directly related to the loss of efficacy of currently accepted Helicobacter pylori therapies. Knowledge of the antibiotic susceptibility in a local area can contribute to the design of specific 'à la carte' treatments. The aim of this study was to analys...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 2012-01, Vol.67 (1), p.170-173
Main Authors: Cuadrado-Lavín, Antonio, Salcines-Caviedes, J. Ramón, Carrascosa, Miguel F., Mellado, Purificación, Monteagudo, Idoia, Llorca, Javier, Cobo, Marta, Campos, M. Rosario, Ayestarán, Blanca, Fernández-Pousa, Antonio, González-Colominas, Elena
Format: Article
Language:English
Subjects:
Adult
Anti-Bacterial Agents - pharmacology
Antibiotics
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacteria
Bacterial diseases
Bacterial diseases of the digestive system and abdomen
Biological and medical sciences
Biopsy
Drug resistance
Drug Resistance, Bacterial
Female
Gastroenterology. Liver. Pancreas. Abdomen
Helicobacter Infections - microbiology
Helicobacter pylori
Helicobacter pylori - drug effects
Helicobacter pylori - isolation & purification
Human bacterial diseases
Humans
Infectious diseases
Male
Medical sciences
Microbial Sensitivity Tests
Other diseases. Semiology
Pharmacology. Drug treatments
Spain
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
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Summary:Background Antibiotic resistance is directly related to the loss of efficacy of currently accepted Helicobacter pylori therapies. Knowledge of the antibiotic susceptibility in a local area can contribute to the design of specific 'à la carte' treatments. The aim of this study was to analyse the susceptibility of H. pylori isolates to six conventional antibiotics currently used in a northern region of Spain. Methods Seventy-one isolates were obtained from gastric biopsies of 76 consecutive adult patients suffering from peptic ulcer disease, dyspepsia or familial gastric cancer and known to be infected with H. pylori by conventional methods. Susceptibility testing was performed for amoxicillin, ciprofloxacin, levofloxacin, clarithromycin, metronidazole and tetracycline using the Etest method. Results The prevalence rates of resistance were as follows: amoxicillin, 1.4% [95% confidence interval (CI) 0.0-7.6]; clarithromycin, 14.7% (95% CI 7.3-25.4); ciprofloxacin, 14.3% (95% CI 7.1-24.7); levofloxacin, 14.5% (95% CI 7.2-25.0); metronidazole, 45.1% (95% CI 33.2-57.3); and tetracycline, 0% (95% CI 0.0-5.1). Conclusions Our study confirms an increasing rate of resistance to levofloxacin that equals that of clarithromycin in our healthcare area. This fact may reflect a wide and indiscriminate use of the former antibiotic and could account for a loss of clinical effectiveness of levofloxacin-containing regimens. Moreover, clarithromycin resistance rates remain stable, which could allow us to maintain its use in our area.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/dkr410