Deregulation of FGFR1 and CDK6 oncogenic pathways in acute lymphoblastic leukaemia harbouring epigenetic modifications of the MIR9 family

Summary The role of epigenetic mechanisms in the regulation of microRNAs (miRNAs) with a tumour‐suppressor function in human neoplasms has recently been established. Several miRNAs have been found to be inappropriately regulated by DNA methylation in patients with acute lymphoblastic leukaemia (ALL)...

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Published in:British journal of haematology 2011-10, Vol.155 (1), p.73-83
Main Authors: Rodriguez‐Otero, Paula, Román‐Gómez, José, Vilas‐Zornoza, Amaia, José‐Eneriz, Edurne San, Martín‐Palanco, Vanesa, Rifón, José, Torres, Antonio, Calasanz, María José, Agirre, Xabier, Prosper, Felipe
Format: Article
Language:English
Subjects:
Acute lymphatic leukemia
acute lymphoblastic leukaemia
Adolescent
Adult
Aged
Aged, 80 and over
Antineoplastic Agents - pharmacology
Apoptosis
Apoptosis - drug effects
Biological and medical sciences
Cell proliferation
Cell Proliferation - drug effects
Child
Child, Preschool
Chromosome Aberrations
CpG Islands - genetics
Cyclin-Dependent Kinase 6 - antagonists & inhibitors
Cyclin-Dependent Kinase 6 - biosynthesis
Cyclin-Dependent Kinase 6 - genetics
DNA Methylation
DNA, Neoplasm - genetics
Down-Regulation
Epigenesis, Genetic
epigenetics
Female
Fibroblast growth factor receptor 1
Gene Expression Regulation, Neoplastic
Hematologic and hematopoietic diseases
Humans
Infant
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
microRNAs
MicroRNAs - genetics
MicroRNAs - physiology
Middle Aged
MIR9
miRNA
Multivariate analysis
oncogenic pathways
Piperazines - pharmacology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism
Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology
Prognosis
Pyridines - pharmacology
Pyrimidines - pharmacology
Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors
Receptor, Fibroblast Growth Factor, Type 1 - biosynthesis
Receptor, Fibroblast Growth Factor, Type 1 - genetics
RNA, Neoplasm - genetics
RNA, Neoplasm - physiology
Signal Transduction - drug effects
Tumor Cells, Cultured
Young Adult
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Summary:Summary The role of epigenetic mechanisms in the regulation of microRNAs (miRNAs) with a tumour‐suppressor function in human neoplasms has recently been established. Several miRNAs have been found to be inappropriately regulated by DNA methylation in patients with acute lymphoblastic leukaemia (ALL). We analysed the methylation status of the three members of the MIR9 family (MIR9‐1, MIR9‐2 and MIR9‐3) in a uniformly treated cohort of 200 newly diagnosed ALLs. MIR9 was methylated in 54% of the patients and was associated with downregulation of MIR9 (P 
ISSN:0007-1048
1365-2141
DOI:10.1111/j.1365-2141.2011.08812.x