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Effects of therapeutic lifestyle changes on peripheral artery tonometry in patients with abdominal obesity
Abstract Background and aims Abdominal obesity (AO) is associated with endothelial function (EF) alteration and increased global cardiovascular (CV) risk. Therapeutic lifestyle changes (TLSC) reduce CV risk, but the impact on EF assessed by peripheral artery tonometry (PAT) is unknown. In this study...
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| Published in: | Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2012-02, Vol.22 (2), p.95-102 |
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| container_title | Nutrition, metabolism, and cardiovascular diseases |
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| creator | Ferré, R Plana, N Merino, J Aragonès, G Girona, J Heras, M Coll, B Cos, R Masana, L |
| description | Abstract Background and aims Abdominal obesity (AO) is associated with endothelial function (EF) alteration and increased global cardiovascular (CV) risk. Therapeutic lifestyle changes (TLSC) reduce CV risk, but the impact on EF assessed by peripheral artery tonometry (PAT) is unknown. In this study, we aimed to prospectively assess the effects of TLSC on EF measured by PAT in increased CV risk patients with AO. Methods and results 150 patients with AO and moderate CV risk were randomized to groups receiving a one-year intervention of either conventional medical care (control group, CG) or an intensive TLSC program (intervention group, IG). Vascular studies (EF by PAT, intima-media thickness (IMT)) and lifestyle (LS) assessment were performed before and after intervention. The PAT ratio improved in the IG and worsened in the CG. The global CV risk was reduced ( P = 0.017) in the IG due to a significant decrease in systolic blood pressure ( P |
| doi_str_mv | 10.1016/j.numecd.2010.04.008 |
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Therapeutic lifestyle changes (TLSC) reduce CV risk, but the impact on EF assessed by peripheral artery tonometry (PAT) is unknown. In this study, we aimed to prospectively assess the effects of TLSC on EF measured by PAT in increased CV risk patients with AO. Methods and results 150 patients with AO and moderate CV risk were randomized to groups receiving a one-year intervention of either conventional medical care (control group, CG) or an intensive TLSC program (intervention group, IG). Vascular studies (EF by PAT, intima-media thickness (IMT)) and lifestyle (LS) assessment were performed before and after intervention. The PAT ratio improved in the IG and worsened in the CG. The global CV risk was reduced ( P = 0.017) in the IG due to a significant decrease in systolic blood pressure ( P < 0.001), increase in HDL cholesterol and ApolipoproteinA1 ( P = 0.013). More individuals in the IG than in the CG quit smoking ( P = 0.001) and increased their physical activity ( P = 0.014). The improvement in at least two LS components was associated with a PAT ratio increase (2.44 IC: 95% 0.99–6.00, P = 0.051). The PAT ratio increase determined less IMT progression (−1.1 IC: 95% 0.91–1.00, P = 0.053). Conclusions Good adherence to a TLSC program reduces global CV risk and determines PAT ratio improvement. The PAT ratio increase is the main determinant of lower IMT progression.</description><identifier>ISSN: 0939-4753</identifier><identifier>EISSN: 1590-3729</identifier><identifier>DOI: 10.1016/j.numecd.2010.04.008</identifier><identifier>PMID: 20708393</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Abdominal obesity ; Adult ; Aged ; Anthropometry ; Arteries - pathology ; Cardiovascular ; Cardiovascular risk ; Endothelial function ; Endothelium - metabolism ; Female ; high density lipoprotein cholesterol ; Humans ; Life Style ; lifestyle ; Male ; Manometry ; Middle Aged ; obesity ; Obesity, Abdominal - complications ; Obesity, Abdominal - therapy ; patients ; Peripheral Arterial Disease - complications ; Peripheral Arterial Disease - therapy ; Peripheral artery tonometry ; physical activity ; Prospective Studies ; risk ; systolic blood pressure ; Therapeutic lifestyle changes ; therapeutics</subject><ispartof>Nutrition, metabolism, and cardiovascular diseases, 2012-02, Vol.22 (2), p.95-102</ispartof><rights>Elsevier B.V.</rights><rights>2010 Elsevier B.V.</rights><rights>Copyright © 2010 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-4d4073ab6eec379e260bbbf63abaa3aec1295bef6bac8ed2b4bcd6d54ff322393</citedby><cites>FETCH-LOGICAL-c440t-4d4073ab6eec379e260bbbf63abaa3aec1295bef6bac8ed2b4bcd6d54ff322393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20708393$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ferré, R</creatorcontrib><creatorcontrib>Plana, N</creatorcontrib><creatorcontrib>Merino, J</creatorcontrib><creatorcontrib>Aragonès, G</creatorcontrib><creatorcontrib>Girona, J</creatorcontrib><creatorcontrib>Heras, M</creatorcontrib><creatorcontrib>Coll, B</creatorcontrib><creatorcontrib>Cos, R</creatorcontrib><creatorcontrib>Masana, L</creatorcontrib><title>Effects of therapeutic lifestyle changes on peripheral artery tonometry in patients with abdominal obesity</title><title>Nutrition, metabolism, and cardiovascular diseases</title><addtitle>Nutr Metab Cardiovasc Dis</addtitle><description>Abstract Background and aims Abdominal obesity (AO) is associated with endothelial function (EF) alteration and increased global cardiovascular (CV) risk. Therapeutic lifestyle changes (TLSC) reduce CV risk, but the impact on EF assessed by peripheral artery tonometry (PAT) is unknown. In this study, we aimed to prospectively assess the effects of TLSC on EF measured by PAT in increased CV risk patients with AO. Methods and results 150 patients with AO and moderate CV risk were randomized to groups receiving a one-year intervention of either conventional medical care (control group, CG) or an intensive TLSC program (intervention group, IG). Vascular studies (EF by PAT, intima-media thickness (IMT)) and lifestyle (LS) assessment were performed before and after intervention. The PAT ratio improved in the IG and worsened in the CG. The global CV risk was reduced ( P = 0.017) in the IG due to a significant decrease in systolic blood pressure ( P < 0.001), increase in HDL cholesterol and ApolipoproteinA1 ( P = 0.013). More individuals in the IG than in the CG quit smoking ( P = 0.001) and increased their physical activity ( P = 0.014). The improvement in at least two LS components was associated with a PAT ratio increase (2.44 IC: 95% 0.99–6.00, P = 0.051). The PAT ratio increase determined less IMT progression (−1.1 IC: 95% 0.91–1.00, P = 0.053). Conclusions Good adherence to a TLSC program reduces global CV risk and determines PAT ratio improvement. The PAT ratio increase is the main determinant of lower IMT progression.</description><subject>Abdominal obesity</subject><subject>Adult</subject><subject>Aged</subject><subject>Anthropometry</subject><subject>Arteries - pathology</subject><subject>Cardiovascular</subject><subject>Cardiovascular risk</subject><subject>Endothelial function</subject><subject>Endothelium - metabolism</subject><subject>Female</subject><subject>high density lipoprotein cholesterol</subject><subject>Humans</subject><subject>Life Style</subject><subject>lifestyle</subject><subject>Male</subject><subject>Manometry</subject><subject>Middle Aged</subject><subject>obesity</subject><subject>Obesity, Abdominal - complications</subject><subject>Obesity, Abdominal - therapy</subject><subject>patients</subject><subject>Peripheral Arterial Disease - complications</subject><subject>Peripheral Arterial Disease - therapy</subject><subject>Peripheral artery tonometry</subject><subject>physical activity</subject><subject>Prospective Studies</subject><subject>risk</subject><subject>systolic blood pressure</subject><subject>Therapeutic lifestyle changes</subject><subject>therapeutics</subject><issn>0939-4753</issn><issn>1590-3729</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNqFkk1v1DAQQCMEokvhHyDIjVOWie0kmwsSqsqHVIlD6dmynXHXIYmD7RTl3zNRCgcunGyN34xnnp1lr0s4llDW7_vjtIxouiMDCoE4ApyeZIeyaqHgDWufZgdoeVuIpuIX2YsYewDeABfPswsGDZx4yw9Zf20tmhRzb_N0xqBmXJIz-eAsxrQOmJuzmu6RgCmfMbh5g4ZchYRhzZOf_IiJdo6OVXI4Ua1fLp1zpTs_uolYrzG6tL7Mnlk1RHz1uF5md5-uv199KW6-ff569fGmMEJAKkQnoOFK14iGNy2yGrTWtqaQUlyhKVlbabS1VuaEHdNCm67uKmEtZ4yGusze7XXn4H8uNIUcXTQ4DGpCv0TZMuB11bSCSLGTJvgYA1o5BzeqsMoS5CZZ9nKXLDfJEoQkyZT25vGCRY_Y_U36Y5WAtztglZfqPrgo726pQgWUXtacEfFhJ5BEPDgMMhpyZ7BzgZ5Ddt79r4d_C5jBTc6o4QeuGHu_BFIfZSkjkyBvt6-w_YSSWiihZfw3XeSxBg</recordid><startdate>20120201</startdate><enddate>20120201</enddate><creator>Ferré, R</creator><creator>Plana, N</creator><creator>Merino, J</creator><creator>Aragonès, G</creator><creator>Girona, J</creator><creator>Heras, M</creator><creator>Coll, B</creator><creator>Cos, R</creator><creator>Masana, L</creator><general>Elsevier B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120201</creationdate><title>Effects of therapeutic lifestyle changes on peripheral artery tonometry in patients with abdominal obesity</title><author>Ferré, R ; Plana, N ; Merino, J ; Aragonès, G ; Girona, J ; Heras, M ; Coll, B ; Cos, R ; Masana, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-4d4073ab6eec379e260bbbf63abaa3aec1295bef6bac8ed2b4bcd6d54ff322393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Abdominal obesity</topic><topic>Adult</topic><topic>Aged</topic><topic>Anthropometry</topic><topic>Arteries - pathology</topic><topic>Cardiovascular</topic><topic>Cardiovascular risk</topic><topic>Endothelial function</topic><topic>Endothelium - metabolism</topic><topic>Female</topic><topic>high density lipoprotein cholesterol</topic><topic>Humans</topic><topic>Life Style</topic><topic>lifestyle</topic><topic>Male</topic><topic>Manometry</topic><topic>Middle Aged</topic><topic>obesity</topic><topic>Obesity, Abdominal - complications</topic><topic>Obesity, Abdominal - therapy</topic><topic>patients</topic><topic>Peripheral Arterial Disease - complications</topic><topic>Peripheral Arterial Disease - therapy</topic><topic>Peripheral artery tonometry</topic><topic>physical activity</topic><topic>Prospective Studies</topic><topic>risk</topic><topic>systolic blood pressure</topic><topic>Therapeutic lifestyle changes</topic><topic>therapeutics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ferré, R</creatorcontrib><creatorcontrib>Plana, N</creatorcontrib><creatorcontrib>Merino, J</creatorcontrib><creatorcontrib>Aragonès, G</creatorcontrib><creatorcontrib>Girona, J</creatorcontrib><creatorcontrib>Heras, M</creatorcontrib><creatorcontrib>Coll, B</creatorcontrib><creatorcontrib>Cos, R</creatorcontrib><creatorcontrib>Masana, L</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nutrition, metabolism, and cardiovascular diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ferré, R</au><au>Plana, N</au><au>Merino, J</au><au>Aragonès, G</au><au>Girona, J</au><au>Heras, M</au><au>Coll, B</au><au>Cos, R</au><au>Masana, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of therapeutic lifestyle changes on peripheral artery tonometry in patients with abdominal obesity</atitle><jtitle>Nutrition, metabolism, and cardiovascular diseases</jtitle><addtitle>Nutr Metab Cardiovasc Dis</addtitle><date>2012-02-01</date><risdate>2012</risdate><volume>22</volume><issue>2</issue><spage>95</spage><epage>102</epage><pages>95-102</pages><issn>0939-4753</issn><eissn>1590-3729</eissn><notes>http://dx.doi.org/10.1016/j.numecd.2010.04.008</notes><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-News-1</notes><notes>ObjectType-Feature-3</notes><notes>content type line 23</notes><abstract>Abstract Background and aims Abdominal obesity (AO) is associated with endothelial function (EF) alteration and increased global cardiovascular (CV) risk. Therapeutic lifestyle changes (TLSC) reduce CV risk, but the impact on EF assessed by peripheral artery tonometry (PAT) is unknown. In this study, we aimed to prospectively assess the effects of TLSC on EF measured by PAT in increased CV risk patients with AO. Methods and results 150 patients with AO and moderate CV risk were randomized to groups receiving a one-year intervention of either conventional medical care (control group, CG) or an intensive TLSC program (intervention group, IG). Vascular studies (EF by PAT, intima-media thickness (IMT)) and lifestyle (LS) assessment were performed before and after intervention. The PAT ratio improved in the IG and worsened in the CG. The global CV risk was reduced ( P = 0.017) in the IG due to a significant decrease in systolic blood pressure ( P < 0.001), increase in HDL cholesterol and ApolipoproteinA1 ( P = 0.013). More individuals in the IG than in the CG quit smoking ( P = 0.001) and increased their physical activity ( P = 0.014). The improvement in at least two LS components was associated with a PAT ratio increase (2.44 IC: 95% 0.99–6.00, P = 0.051). The PAT ratio increase determined less IMT progression (−1.1 IC: 95% 0.91–1.00, P = 0.053). Conclusions Good adherence to a TLSC program reduces global CV risk and determines PAT ratio improvement. The PAT ratio increase is the main determinant of lower IMT progression.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>20708393</pmid><doi>10.1016/j.numecd.2010.04.008</doi><tpages>8</tpages></addata></record> |
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| subjects | Abdominal obesity Adult Aged Anthropometry Arteries - pathology Cardiovascular Cardiovascular risk Endothelial function Endothelium - metabolism Female high density lipoprotein cholesterol Humans Life Style lifestyle Male Manometry Middle Aged obesity Obesity, Abdominal - complications Obesity, Abdominal - therapy patients Peripheral Arterial Disease - complications Peripheral Arterial Disease - therapy Peripheral artery tonometry physical activity Prospective Studies risk systolic blood pressure Therapeutic lifestyle changes therapeutics |
| title | Effects of therapeutic lifestyle changes on peripheral artery tonometry in patients with abdominal obesity |
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