Effects of therapeutic lifestyle changes on peripheral artery tonometry in patients with abdominal obesity

Abstract Background and aims Abdominal obesity (AO) is associated with endothelial function (EF) alteration and increased global cardiovascular (CV) risk. Therapeutic lifestyle changes (TLSC) reduce CV risk, but the impact on EF assessed by peripheral artery tonometry (PAT) is unknown. In this study...

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Bibliographic Details
Published in:Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2012-02, Vol.22 (2), p.95-102
Main Authors: Ferré, R, Plana, N, Merino, J, Aragonès, G, Girona, J, Heras, M, Coll, B, Cos, R, Masana, L
Format: Article
Language:English
Subjects:
Abdominal obesity
Adult
Aged
Anthropometry
Arteries - pathology
Cardiovascular
Cardiovascular risk
Endothelial function
Endothelium - metabolism
Female
high density lipoprotein cholesterol
Humans
Life Style
lifestyle
Male
Manometry
Middle Aged
obesity
Obesity, Abdominal - complications
Obesity, Abdominal - therapy
patients
Peripheral Arterial Disease - complications
Peripheral Arterial Disease - therapy
Peripheral artery tonometry
physical activity
Prospective Studies
risk
systolic blood pressure
Therapeutic lifestyle changes
therapeutics
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Summary:Abstract Background and aims Abdominal obesity (AO) is associated with endothelial function (EF) alteration and increased global cardiovascular (CV) risk. Therapeutic lifestyle changes (TLSC) reduce CV risk, but the impact on EF assessed by peripheral artery tonometry (PAT) is unknown. In this study, we aimed to prospectively assess the effects of TLSC on EF measured by PAT in increased CV risk patients with AO. Methods and results 150 patients with AO and moderate CV risk were randomized to groups receiving a one-year intervention of either conventional medical care (control group, CG) or an intensive TLSC program (intervention group, IG). Vascular studies (EF by PAT, intima-media thickness (IMT)) and lifestyle (LS) assessment were performed before and after intervention. The PAT ratio improved in the IG and worsened in the CG. The global CV risk was reduced ( P  = 0.017) in the IG due to a significant decrease in systolic blood pressure ( P  
ISSN:0939-4753
1590-3729
DOI:10.1016/j.numecd.2010.04.008