Apoptosis in the anucleate platelet

Abstract For many years, programmed cell death, known as apoptosis, was attributed exclusively to nucleated cells. Currently, however, apoptosis is also well-documented in anucleate platelets. This review describes extrinsic and intrinsic pathways of apoptosis in nucleated cells and in platelets, pl...

Full description

Saved in:
Bibliographic Details
Published in:Blood reviews 2012-03, Vol.26 (2), p.51-63
Main Author: Leytin, Valery
Format: Article
Language:English
Subjects:
Apoptosis
Apoptosis triggers and markers
Biological and medical sciences
Blood Platelets - cytology
Blood Platelets - metabolism
Blood Platelets - ultrastructure
Cyclosporin A
Eptifibatide (Integrilin)
Extrinsic and intrinsic apoptosis pathways
Hematologic and hematopoietic diseases
Hematology, Oncology and Palliative Medicine
Humans
Intravenous immunoglobulin
Medical sciences
Microscopy, Electron, Scanning
Mitochodrial control
Mitochondria - metabolism
PAR-1, GPIIbIIIa, GPIbα receptors
Platelet apoptosis
Platelet Membrane Glycoproteins - metabolism
Shear stress
Tirofiban (Aggrastat)
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract For many years, programmed cell death, known as apoptosis, was attributed exclusively to nucleated cells. Currently, however, apoptosis is also well-documented in anucleate platelets. This review describes extrinsic and intrinsic pathways of apoptosis in nucleated cells and in platelets, platelet apoptosis induced by multiple chemical stimuli and shear stresses, markers of platelet apoptosis, mitochodrial control of platelet apoptosis, and apoptosis mediated by platelet surface receptors PAR-1, GPIIbIIIa and GPIbα. In addition, this review presents data on platelet apoptosis provoked by aging of platelets in vitro during platelet storage, platelet apoptosis in pathological settings in humans and animal models, and inhibition of platelet apoptosis by cyclosporin A, intravenous immunoglobulin and GPIIbIIIa antagonist drugs.
ISSN:0268-960X
1532-1681
DOI:10.1016/j.blre.2011.10.002