Association of subcutaneous and visceral fat mass with serum concentrations of adipokines in subjects with type 2 diabetes mellitus

The goal of the study was to examine the association of subcutaneous and visceral fat mass with serum concentrations of adipokines in 130 subjects with type 2 diabetes mellitus. The levels of serum high sensitivity C-reactive protein (HS-CRP), adiponectin, high-molecular-weight (HMW) adiponectin, in...

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Bibliographic Details
Published in:Endocrine Journal 2012, Vol.59(1), pp.39-45
Main Authors: Saito, Tomoyuki, Murata, Miho, Otani, Taeko, Tamemoto, Hiroyuki, Kawakami, Masanobu, Ishikawa, San-e
Format: Article
Language:English
Subjects:
Adipokines
Adipokines - blood
Adiponectin
Adiponectin - blood
Adiponectin - chemistry
Adiposity
Adolescent
Adult
Aged
Aged, 80 and over
Body Mass Index
C-reactive protein
C-Reactive Protein - analysis
Cross-Sectional Studies
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - immunology
Diabetes Mellitus, Type 2 - pathology
Female
Humans
Intra-Abdominal Fat - immunology
Intra-Abdominal Fat - pathology
Male
Middle Aged
Molecular Weight
Obesity - complications
Sex Characteristics
Subcutaneous Fat, Abdominal - immunology
Subcutaneous Fat, Abdominal - pathology
Type 2 diabetes mellitus
Visceral fat
Young Adult
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Summary:The goal of the study was to examine the association of subcutaneous and visceral fat mass with serum concentrations of adipokines in 130 subjects with type 2 diabetes mellitus. The levels of serum high sensitivity C-reactive protein (HS-CRP), adiponectin, high-molecular-weight (HMW) adiponectin, interleukin-18, and retinol-binding protein 4 were measured. Percentage body fat was determined by dual energy X-ray absorptiometry, and subcutaneous and visceral fat areas were measured by abdominal CT. HS-CRP had significant positive correlations with percentage body fat and subcutaneous fat area, and a particularly significant positive correlation with visceral fat area. Serum adiponectin had a negative correlation with the subcutaneous and visceral fat areas, with the strongest correlation with the visceral fat area. Similar results were obtained for HMW adiponectin. Serum adiponectin had a negative correlation with visceral fat area in subjects with a visceral fat area < 100 cm2, but not in those with a visceral fat area ≥ 100 cm2. In contrast, serum HS-CRP showed a positive correlation with visceral fat area in subjects with visceral fat area ≥ 100 cm2, but not in those with a visceral fat area < 100 cm2. These findings indicate that an increased visceral fat area is associated with inflammatory changes, and that inflammatory reactions may alter the functional properties of visceral fat in type 2 diabetes mellitus.
ISSN:0918-8959
1348-4540
DOI:10.1507/endocrj.EJ11-0132