Age- and sex-related differences in the acquisition and reinstatement of ethanol CPP in mice

Abstract Many people begin to experiment with alcohol during adolescence, an important developmental period during which sex differences in the effects of ethanol appear. In the present study we evaluated the effect of ethanol (0, 0.625, 1.25 or 2.5 g/kg) on the acquisition of a conditioned place pr...

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Bibliographic Details
Published in:Neurotoxicology and teratology 2012-01, Vol.34 (1), p.108-115
Main Authors: Roger-Sánchez, C, Aguilar, M.A, Rodríguez-Arias, M, Aragon, C.M, Miñarro, J
Format: Article
Language:English
Subjects:
Adolescence
Age Factors
Alcohol-Induced Disorders, Nervous System - etiology
Alcoholism - etiology
Alcoholism and acute alcohol poisoning
Animals
Animals, Outbred Strains
Biological and medical sciences
Causality
Central Nervous System Depressants - blood
Central Nervous System Depressants - toxicity
Conditioned place preference
Conditioning (Psychology) - drug effects
Conditioning (Psychology) - physiology
Disease Models, Animal
Emergency
Ethanol
Ethanol - blood
Ethanol - toxicity
Female
Learning Disorders - etiology
Male
Medical Education
Medical sciences
Mice
Reinstatement
Repetition Priming - drug effects
Repetition Priming - physiology
Sex Characteristics
Sex differences
Toxicology
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Summary:Abstract Many people begin to experiment with alcohol during adolescence, an important developmental period during which sex differences in the effects of ethanol appear. In the present study we evaluated the effect of ethanol (0, 0.625, 1.25 or 2.5 g/kg) on the acquisition of a conditioned place preference (CPP) in early and late adolescent male and female mice. In addition, we assessed the capacity of ethanol to induce reinstatement of the CPP after its extinction. CPP was induced in early and late adolescent females with 2.5 g/kg, and in early adolescent males with 1.25 or 2.5 g/kg of ethanol. No CPP was observed in late adolescent males. Priming with ethanol reinstated the CPP induced by the highest dose in early adolescent male and early and late adolescent female mice. Our data suggest that early adolescents of both sex and late adolescent females are particularly vulnerable to the effects of ethanol.
ISSN:0892-0362
1872-9738
DOI:10.1016/j.ntt.2011.07.011