Paraneoplastic syndrome in mice bearing high-angiogenic variant of Lewis lung carcinoma: Relations with tumor derived VEGF

► High (LLC/R9) and low (LLC) angiogenic variants of Lewis lung carcinoma were used in the study. ► LLC/R9 was characterized by higher rate of VEGF secretion in vitro and elevated level of plasma VEGF in vivo as compared to LLC. ► Paraneoplastic hematological syndrome was observed in LLC/R9-bearing...

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Published in:Cytokine (Philadelphia, Pa.) Pa.), 2012-01, Vol.57 (1), p.81-88
Main Authors: Fedorchuk, Olexander G., Pyaskovskaya, Olga M., Skivka, Larysa M., Gorbik, Gregory V., Trompak, Omelyan O., Solyanik, Galina I.
Format: Article
Language:English
Subjects:
Anemia - blood
Anemia - complications
Animals
Carcinoma, Lewis Lung - blood
Carcinoma, Lewis Lung - blood supply
Carcinoma, Lewis Lung - complications
Carcinoma, Lewis Lung - pathology
Cell Proliferation
Hematopoiesis, Extramedullary
High angiogenic variant of Lewis lung carcinoma
Kinetics
Liver - metabolism
Liver - pathology
Male
Mice
Mice, Inbred C57BL
Neoplasm Transplantation
Neovascularization, Pathologic - blood
Neovascularization, Pathologic - complications
Organ Size
Paraneoplastic syndrome
Paraneoplastic Syndromes - blood
Paraneoplastic Syndromes - complications
Paraneoplastic Syndromes - pathology
Spleen - metabolism
Spleen - pathology
Thymus Gland - pathology
Vascular Endothelial Growth Factor A - blood
Vascular Endothelial Growth Factor A - metabolism
VEGF
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Summary:► High (LLC/R9) and low (LLC) angiogenic variants of Lewis lung carcinoma were used in the study. ► LLC/R9 was characterized by higher rate of VEGF secretion in vitro and elevated level of plasma VEGF in vivo as compared to LLC. ► Paraneoplastic hematological syndrome was observed in LLC/R9-bearing mice. ► The signs of the syndrome were expressed at early stages of tumor growth. ► These precocious signs may be considered as early markers of high angiogenic potential of the tumor. It is well-known that tumor exerts nonmetastatic systemic effect on organism caused the development of paraneoplastic syndrome (PNS). Recent findings point to relationships between development of PNS and tumor-derived vascular endothelial growth factor (VEGF). Comparative study of PNS manifestations in mice with transplanted two variants of Lewis lung carcinoma with different angiogenic potential. Plasma VEGF level was determined by immunoenzyme method, hematological indices were estimated with the use of hematological analyzer, the weight and cellularity of spleen and thymus were registered and histological analysis of tissue section of these organs was performed. Manifestations of anemia, extramedullary hemopoiesis and tumor-associated inflammatory disease was observed in animals with high angiogenic LLC/R9 variant and was not registered in low angiogenic LLC. The emergence of PNS symptoms correlated with elevated level of circulating VEGF at the early stages of LLC/R9 growth. Manifestation of the paraneoplastic hematological syndrome most likely is conditioned on the ability of cancer cell to secrete VEGF in a high rate.
ISSN:1043-4666
1096-0023
DOI:10.1016/j.cyto.2011.10.022