Long-Term Effect of Phytoestrogens from Curcuma comosa Roxb. on Vascular Relaxation in Ovariectomized Rats

Phytoestrogens have been implicated as promising therapeutic agents to treat the vascular impairment seen in menopausal women. The present study investigated the long-term effects of phytoestrogens from Curcuma comosa Roxb. on vascular relaxation of isolated thoracic aorta from ovariectomized (OVX)...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 2012-01, Vol.60 (3), p.758-764
Main Authors: Intapad, Suttira, Saengsirisuwan, Vitoon, Prasannarong, Mujalin, Chuncharunee, Aporn, Suvitayawat, Wisuda, Chokchaisiri, Ratchanaporn, Suksamrarn, Apichart, Piyachaturawat, Pawinee
Format: Article
Language:English
Subjects:
Animals
aorta
Aorta, Thoracic - drug effects
Aorta, Thoracic - physiology
Biological and medical sciences
Curcuma
Curcuma - chemistry
Disease Models, Animal
endothelial cells
Female
Food industries
Fundamental and applied biological sciences. Psychology
hexane
Humans
long term effects
Menopause - drug effects
Menopause - physiology
nitric oxide synthase
nitroprusside
Ovariectomy
Phytoestrogens - pharmacology
plant estrogens
Plant Extracts
protein synthesis
Rats
Rats, Sprague-Dawley
Time Factors
tumor necrosis factor-alpha
Vasodilation - drug effects
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Summary:Phytoestrogens have been implicated as promising therapeutic agents to treat the vascular impairment seen in menopausal women. The present study investigated the long-term effects of phytoestrogens from Curcuma comosa Roxb. on vascular relaxation of isolated thoracic aorta from ovariectomized (OVX) rats. Treatment of OVX rats for 12 weeks with C. comosa powder, hexane extract, and a novel phytoestrogen, diarylheptanoid-D3, [(3R)-1,7-diphenyl-(4E,6E)-4,6-heptadien-3-ol] prevented impairment of the endothelium-dependent relaxation response to acetylcholine in OVX, but not the endothelium-denude aortic ring relaxation in response to sodium nitroprusside. These data suggest that the vascular relaxation effect of C. comosa is mediated via endothelial cells. Treatment with D3 also increased endothelial nitric oxide synthase (eNOS) and estrogen receptor-α (ERα) protein expression in the aorta of OVX rats and suppressed elevated tumor necrosis factor-α (TNF-α) expression in OVX aortic rings. These results indicate that C. comosa treatment prevents impairment of vascular relaxation in estrogen-deficient animals via the ER-eNOS pathway as well as through its ability to promote an anti-inflammatory response.
ISSN:0021-8561
1520-5118
DOI:10.1021/jf203173b