Corneal Hysteresis and Beta-Zone Parapapillary Atrophy

Purpose To evaluate the relationship between β-zone parapapillary atrophy (βPPA) and corneal hysteresis (CH) in patients with glaucoma. Design Prospective, cross-sectional study. Methods Glaucoma patients aged 18 to 90 years with disc photographs within 12 months of the study visit were consecutivel...

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Bibliographic Details
Published in:American journal of ophthalmology 2012-02, Vol.153 (2), p.358-362.e1
Main Authors: Hayes, Daniel D, Teng, Christopher C, de Moraes, Carlos Gustavo, Tello, Celso, Liebmann, Jeffrey M, Ritch, Robert
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Biomechanical Phenomena
Cornea - physiology
Cross-Sectional Studies
Elasticity - physiology
Female
Glaucoma
Glaucoma - physiopathology
Humans
Intraocular Pressure - physiology
Male
Medical sciences
Middle Aged
Miscellaneous
Ophthalmology
Optic Atrophy - physiopathology
Optic Disk - pathology
Pliability - physiology
Prospective Studies
Software
Therapy
Tonometry, Ocular
Young Adult
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Summary:Purpose To evaluate the relationship between β-zone parapapillary atrophy (βPPA) and corneal hysteresis (CH) in patients with glaucoma. Design Prospective, cross-sectional study. Methods Glaucoma patients aged 18 to 90 years with disc photographs within 12 months of the study visit were consecutively enrolled. Exclusion criteria included ocular surgery other than clear corneal phacoemulsification, myopia >6 diopters, contact lens use, and corneal abnormality. CH was measured using the Ocular Response Analyzer (ORA). Disc photographs were evaluated in a masked fashion for βPPA. Results We enrolled 99 patients (mean age 67.6 years; 45 men, 54 women). Univariate analysis showed no significant difference in CH between eyes with and without βPPA (8.72 ± 0.23 vs 8.15 ± 0.27 mm Hg, P = .11). There were no differences in corneal resistance factor (CRF) ( P = .47), central corneal thickness (CCT) ( P = .11), ORA wave score ( P = .23), age ( P = .23), sex ( P = .40), IOP ( P = .86), or visual field mean deviation (VFMD) ( P = .45). Eyes with βPPA were more myopic (−1.49 ± 0.27 vs −0.22 ± 0.31 diopters, P = .003). Multivariate analysis showed no significant difference in CH between eyes with and without βPPA ( P = .38). Eyes with asymmetric βPPA also showed no significant difference in CH (8.97 ± 0.22 vs 9.10 ± 0.22 mm Hg, P = .69). Conclusions We found no significant differences in CH between eyes with and without βPPA or between fellow eyes with asymmetric βPPA.
ISSN:0002-9394
1879-1891
DOI:10.1016/j.ajo.2011.06.025