Profiles of Receptive and Expressive Language Abilities in Boys with Comorbid Fragile X Syndrome and Autism

The authors examined receptive and expressive language profiles for a group of verbal male children and adolescents who had fragile X syndrome along with varying degrees of autism symptoms. A categorical approach for assigning autism diagnostic classification, based on the combined use of the Autism...

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Bibliographic Details
Published in:	American journal on intellectual and developmental disabilities 2012-01, Vol.117 (1), p.18-32
Main Authors:	McDuffie, Andrea, Kover, Sara, Abbeduto, Leonard, Lewis, Pamela, Brown, Ted
Format:	Article
Language:	eng
Subjects:	Adolescent Adults Autism Autism Diagnostic Observation Schedule Autistic Disorder - classification Autistic Disorder - epidemiology Biological and medical sciences Child Child clinical studies Children Children & youth Communication Disorders - epidemiology Comorbidity Congenital Impairments Developmental disorders Effect Size Expressive Language Fragile X Syndrome - epidemiology Genetic Disorders Humans Infantile autism Intelligence Quotient Language acquisition Language Development Disorders - epidemiology Language Skills Language Tests Male Males Medical sciences Mental Retardation Nonverbal Ability Nonverbal Communication Pervasive Developmental Disorders Profiles Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Receptive Language Semantics Severity (of Disability) Severity of Illness Index Standardized Tests Syntax Vocabulary
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Summary:	The authors examined receptive and expressive language profiles for a group of verbal male children and adolescents who had fragile X syndrome along with varying degrees of autism symptoms. A categorical approach for assigning autism diagnostic classification, based on the combined use of the Autism Diagnostic Interview--Revised and the Autism Diagnostic Observation Schedule (ADOS), and a continuous approach for representing autism symptom severity, based on ADOS severity scores, were used in 2 separate sets of analyses. All analyses controlled for nonverbal IQ and chronological age. Nonverbal IQ accounted for significant variance in all language outcomes with large effect sizes. Results of the categorical analyses failed to reveal an effect of diagnostic group (fragile X syndrome--autism, fragile X syndrome--no autism) on standardized language test performance. Results of the continuous analyses revealed a negative relationship between autism symptom severity and all of the standardized language measures. Implications for representing autism symptoms in fragile X syndrome research are considered.
ISSN:	1944-7515 1944-7558