Perinatal mortality and morbidity in twin pregnancies: the relation between chorionicity and gestational age at birth

Aim To investigate perinatal mortality and morbidity rates of twin pregnancies and to determine the underlying factors responsible for the increase in these rates. Methods Records of 300 twin pregnancies which have been followed in our clinic between 1996 and 2005 were reviewed retrospectively. Peri...

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Bibliographic Details
Published in:Archives of gynecology and obstetrics 2012-02, Vol.285 (2), p.353-360
Main Authors: Gezer, Altay, Rashidova, Muhabbet, Güralp, Onur, Öçer, Fahri
Format: Article
Language:English
Subjects:
Adolescent
Adult
Chorion - anatomy & histology
Comparative analysis
Congenital Abnormalities - mortality
Endocrinology
Female
Fetal Death - epidemiology
Gestational Age
Gynecology
Health risk assessment
Human Genetics
Humans
Infant Mortality
Infant, Newborn
Intensive Care, Neonatal - statistics & numerical data
Maternal Age
Maternal-Fetal Medicine
Medicine
Medicine & Public Health
Morbidity
Mortality
Obstetrics/Perinatology/Midwifery
Perinatal Mortality
Positive-Pressure Respiration
Pregnancy
Pregnancy, Twin
Premature Birth - mortality
Respiratory distress syndrome
Respiratory Distress Syndrome, Newborn - epidemiology
Respiratory Distress Syndrome, Newborn - therapy
Retrospective Studies
Turkey - epidemiology
Young Adult
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Summary:Aim To investigate perinatal mortality and morbidity rates of twin pregnancies and to determine the underlying factors responsible for the increase in these rates. Methods Records of 300 twin pregnancies which have been followed in our clinic between 1996 and 2005 were reviewed retrospectively. Perinatal mortality and morbidity rates, zygocity, chorionicity, gestational age at delivery, route of conception, birth weight, route of delivery, fetal gender and cesarean rates were investigated. Results A total of 16,549 deliveries have been reviewed and 2.9% ( n  = 484) of these were detected to be twin deliveries. Perinatal mortality, adjusted perinatal mortality, fetal loss, neonatal mortality and perinatal morbidity rates were 7.5, 6.9, 3, 5.8 and 15.4%, respectively. The principal causes of perinatal mortality were prematurity, fetal demise and congenital abnormalities. The main cause of morbidity was respiratory distress syndrome (RDS). In neonatal period 28% of newborns needed neonatal intensive care unit (NICU) and 12.1% received positive pressured ventilation (PPV). Perinatal mortality and morbidity rates were found to be independent from zygocity, instead they were closely linked with chorionicity. Perinatal mortality and morbidity were higher if maternal age was under 18 and over 35, and were not effected by intrauterine growth retardation (IUGR), discordance between twins or RDS prophylaxis. Conclusion Twin pregnancies have higher perinatal mortality and morbidity rates and potential obstetrical complications compared to singleton pregnancies, therefore should be monitored more intensely, appropriate precautions should be taken against obstetrical complications, especially before 31–32 weeks of gestation, deliveries should be performed in referral centers with competent NICUs.
ISSN:0932-0067
1432-0711
DOI:10.1007/s00404-011-1973-z