Clinicopathological characteristics of ovarian carcinomas associated with endometriosis

Introduction Substantial histopathology data provide evidence that endometriosis might be viewed as a precursor lesion of endometrioid and clear cell carcinoma of the ovary, via intermediary atypical borderline lesions. Also, genes involved in both endometriosis and epithelial ovarian cancer have be...

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Bibliographic Details
Published in:Archives of gynecology and obstetrics 2012-02, Vol.285 (2), p.479-483
Main Authors: Kondi-Pafiti, A., Papakonstantinou, E., Iavazzo, C., Grigoriadis, C., Salakos, N., Gregoriou, O.
Format: Article
Language:English
Subjects:
Adenocarcinoma, Clear Cell - complications
Adenocarcinoma, Clear Cell - pathology
Adenocarcinoma, Clear Cell - therapy
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Carboplatin - administration & dosage
Carcinoma, Endometrioid - complications
Carcinoma, Endometrioid - pathology
Carcinoma, Endometrioid - therapy
Chemotherapy, Adjuvant
Endocrinology
Endometrial cancer
Endometriosis
Endometriosis - complications
Female
Gynecologic Oncology
Gynecology
Human Genetics
Humans
Hysterectomy
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Staging
Obstetrics/Perinatology/Midwifery
Ovarian cancer
Ovarian Neoplasms - complications
Ovarian Neoplasms - pathology
Ovarian Neoplasms - therapy
Ovariectomy
Paclitaxel - administration & dosage
Retrospective Studies
Salpingectomy
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Summary:Introduction Substantial histopathology data provide evidence that endometriosis might be viewed as a precursor lesion of endometrioid and clear cell carcinoma of the ovary, via intermediary atypical borderline lesions. Also, genes involved in both endometriosis and epithelial ovarian cancer have been shown to play a role in the pathogenesis of endometriosis-associated ovarian carcinoma. Material and methods A retrospective study of 17 cases of ovarian carcinomas associated with endometriosis, diagnosed between 2000 and 2009, at Aretaieion Hospital of University of Athens, is presented. 10/17 cases in this study (58.8%) were clear cell carcinomas (CCC), 6/17 cases (35.3%) were endometrioid adenocarcinomas (EAC) and 1/17 cases (5.9%) was a serous carcinoma associated with ovarian endometriosis. Patients’s age was 27–76 years (mean age 58 years). Typical ovarian endometriosis was documented in 8/17 (47%) of the tumors. In 9/17 cases, areas of fibrosis or cystic lesions infiltrated by iron-laden macrophages and endometrial-like stroma, consistent with endometriosis, were observed. Conclusion In comparison with common epithelial ovarian cancers, CCC and EACs of the ovary were presented at earlier stages. Cytoreductive surgical treatment is critical in order to plan appropriate post-operative management.
ISSN:0932-0067
1432-0711
DOI:10.1007/s00404-011-1957-z