Second Messengers cAMP, Ca2+, and NO Modulate Functional Properties of Human Lymphocytes under Conditions of Exposure to UV Light

We studied the effect of UV light (240–390 nm) in doses of 75.5-4530 J/m 2 on functional properties and level of intracellular messengers (cAMP, Ca 2+ , NO) in lymphocytic cells of the peripheral blood. Correcting effects of UV light in a dose of 151 J/m 2 on cytotoxic activity of lymphocytes agains...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2011-04, Vol.150 (6), p.696-699
Main Authors: Nakvasina, M. A., Lidokhova, O. V., Popova, L. I., Trubitsyna, M. S., Artyukhov, V. G.
Format: Article
Language:English
Subjects:
Adenylyl Cyclases - metabolism
Animals
Biomedical and Life Sciences
Biomedicine
Calcium - analysis
Carcinoma, Ehrlich Tumor - immunology
Cell Biology
Cyclic AMP - metabolism
Humans
Internal Medicine
Laboratory Medicine
Lymphocytes - cytology
Lymphocytes - metabolism
Mice
Nitric Oxide - metabolism
Pathology
Second Messenger Systems
Signal Transduction
Tumor Cells, Cultured
Ultraviolet Rays - adverse effects
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Summary:We studied the effect of UV light (240–390 nm) in doses of 75.5-4530 J/m 2 on functional properties and level of intracellular messengers (cAMP, Ca 2+ , NO) in lymphocytic cells of the peripheral blood. Correcting effects of UV light in a dose of 151 J/m 2 on cytotoxic activity of lymphocytes against Ehrlich ascetic carcinoma and calcium concentration in lymphocyte cytosol were observed. We found that UV light reduces the cAMP content and increases NO concentration (151–4530 J/m 2 ) in photomodified cells. The involvement of adenylate cyclase and phosphoinositide signaling pathway into the mechanisms of modulation of functional properties of lymphocytes after exposure to UV light was demonstrated.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-011-1226-y