Biochemical sensor tubing for point-of-care monitoring of intravenous drugs and metabolites

In medical facilities, there is strong motivation to develop detection systems that can provide continuous analysis of fluids in medical tubing used to either deliver or remove fluids from a patient's body. Possible applications include systems that increase the safety of intravenous (IV) drug...

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Bibliographic Details
Published in:Lab on a chip 2012-02, Vol.12 (3), p.574-581
Main Authors: Choi, Charles J, Wu, Hsin-Yu, George, Sherine, Weyhenmeyer, Jonathan, Cunningham, Brian T
Format: Article
Language:English
Subjects:
Biosensing Techniques - instrumentation
Biosensing Techniques - methods
Humans
Injections, Intravenous - methods
Nanoparticles - chemistry
Pain - drug therapy
Point-of-Care Systems - standards
Promethazine - therapeutic use
Spectrum Analysis, Raman - instrumentation
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Summary:In medical facilities, there is strong motivation to develop detection systems that can provide continuous analysis of fluids in medical tubing used to either deliver or remove fluids from a patient's body. Possible applications include systems that increase the safety of intravenous (IV) drug injection and point-of-care health monitoring. In this work, we incorporated a surface-enhanced Raman scattering (SERS) sensor comprised of an array of closely spaced metal nanodomes into flexible tubing commonly used for IV drug delivery and urinary catheters. The nanodome sensor was fabricated by a low-cost, large-area process that enables single use disposable operation. As exemplary demonstrations, the sensor was used to kinetically detect promethazine (pain medication) and urea (urinary metabolite) within their clinically relevant concentration ranges. Distinct SERS peaks for each analyte were used to demonstrate separate detection and co-detection of the analytes.
ISSN:1473-0197
1473-0189
DOI:10.1039/c2lc20586f