Personalized assessment of oxidative cellular damages associated with diabetes using erythrocytes adhesion assay

Increased generation of reactive oxygen species (ROS) is recognized as a prominent feature of vascular dysfunction with diabetes. For self-monitoring of the risk of diabetic complications, we proposed a simple adhesion test of erythrocytes using positively charged surfaces and its adhesion property...

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Bibliographic Details
Published in:Journal of bioscience and bioengineering 2011-12, Vol.112 (6), p.635-637
Main Authors: Okochi, Mina, Sakai, Yuki, Isaji, Yayoi, Nagasaki, Hiroshi, Hamada, Yoji, Honda, Hiroyuki
Format: Article
Language:English
Subjects:
adhesion
Biological and medical sciences
Biotechnology
Cell Adhesion
Cytological Techniques - methods
Diabetes
Diabetic Angiopathies - blood
Diabetic Angiopathies - diagnosis
Diabetic Angiopathies - pathology
diabetic complications
Erythrocytes
Erythrocytes - cytology
Fundamental and applied biological sciences. Psychology
Glycated Hemoglobin A - analysis
HbA 1c
Humans
Oxidative Stress
patients
reactive oxygen species
risk
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Summary:Increased generation of reactive oxygen species (ROS) is recognized as a prominent feature of vascular dysfunction with diabetes. For self-monitoring of the risk of diabetic complications, we proposed a simple adhesion test of erythrocytes using positively charged surfaces and its adhesion property was found to correlate HbA 1c level in diabetic patients.
ISSN:1389-1723
1347-4421
DOI:10.1016/j.jbiosc.2011.08.003