Arterial stiffness, central blood pressure and body size in health and disease

Body size is associated with increased brachial systolic blood pressure (SBP) and aortic stiffness. The aims of this study were to determine the relationships between central SBP and body size (determined by body mass index (BMI), waist circumference and waist/hip ratio) in health and disease. We al...

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Bibliographic Details
Published in:International Journal of Obesity 2012-01, Vol.36 (1), p.93-99
Main Authors: KOLADE, O. O, O'MOORE-SULLIVAN, T. M, STOWASSER, M, COOMBES, J. S, FASSETT, R. G, MARWICK, T. H, SHARMAN, J. E
Format: Article
Language:English
Subjects:
Arteries
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Blood Flow Velocity
Blood Pressure
Body Mass Index
Body size
Brachial Artery - physiopathology
Cardiology. Vascular system
Cardiovascular disease
Cardiovascular Diseases - blood
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - physiopathology
Chronic Disease
Coronary vessels
Cross-Sectional Studies
Diabetes
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - epidemiology
Diabetes Mellitus, Type 2 - physiopathology
Echocardiography
Female
Hospitals
Humans
Hypertension
Kidney diseases
Kidney Failure, Chronic - blood
Kidney Failure, Chronic - epidemiology
Kidney Failure, Chronic - physiopathology
Male
Manometry
Medical sciences
Medicine
Metabolic diseases
Metabolism
Middle Aged
Miscellaneous
Obesity
Patients
Physiological aspects
Predictive Value of Tests
Public health. Hygiene
Public health. Hygiene-occupational medicine
Pulsatile Flow
Risk Factors
Sphygmomanometers
Ultrasonic imaging
Vascular Stiffness
Vein & artery diseases
Waist Circumference
Waist-Hip Ratio
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Description
Summary:Body size is associated with increased brachial systolic blood pressure (SBP) and aortic stiffness. The aims of this study were to determine the relationships between central SBP and body size (determined by body mass index (BMI), waist circumference and waist/hip ratio) in health and disease. We also sought to determine if aortic stiffness was correlated with body size, independent of BP. BMI, brachial BP and estimated central SBP (by SphygmoCor and radial P2) were recorded in controls (n=228), patients with diabetes (n=211), coronary artery disease (n=184) and end-stage kidney disease (n=68). Additional measures of waist circumference and arterial stiffness (aortic and brachial pulse wave velocity (PWV)) were recorded in a subgroup of 75 controls (aged 51 ± 12 years) who were carefully screened for factors affecting vascular function. BMI was associated with brachial (r=0.30; P
ISSN:0307-0565
1476-5497
DOI:10.1038/ijo.2011.79