Pharmacokinetic Properties of Fibre Materials Modified by Co-Immobilization of Different Biologically Active Substances

The possibility of manufacturing dressings with a combined biological action by modifying fibre materials of different types with combined immobilization of an enzyme -- protease C -- and a polymeric antimicrobial -- polyhexamethyleneguanidine hydrochloride or polyethyleneimine with glutaraldehyde -...

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Bibliographic Details
Published in:Fibre chemistry 2001-07, Vol.33 (4), p.282-287
Main Authors: Yudanova, T N, Skokova, I F, Bochkareva, O N, Gal'braikh, L S
Format: Article
Language:English
Subjects:
Enzymes
Fibre
Glutaraldehyde
Hydrochlorides
Immobilization
Polyetherimides
Polyethyleneimine
Protease
Online Access:Get full text
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Summary:The possibility of manufacturing dressings with a combined biological action by modifying fibre materials of different types with combined immobilization of an enzyme -- protease C -- and a polymeric antimicrobial -- polyhexamethyleneguanidine hydrochloride or polyethyleneimine with glutaraldehyde -- was demonstrated. It was shown that with respect to the maximum stability of the enzyme, the fibre materials used for immobilization of protease C together with PEI or PHMG are in the order: PCA > CG > CG--PE. It was found that fibre materials containing immobilized protease C and polyhexamethyleneguanidine hydrochloride or polyethyleneimine exhibit a higher level of activity than the native enzyme at pH 6-9 corresponding to the conditions of use.[PUBLICATION ABSTRACT]
ISSN:0015-0541
1573-8493
DOI:10.1023/A:1012994631958